摘要
通过子宫内灌注盐酸环丙沙星,采用内标法以反相高效液相色谱法测定了4头患子宫内膜炎的奶牛乳汁中盐酸环丙沙星的药物浓度。研究表明,在奶牛给药后0 h^24 h,血药浓度大于乳药浓度,在24 h后,乳药浓度大于血药浓度。在48 h内盐酸环丙沙星的乳药浓度值均高于MIC值,所以仍具有抑菌作用,这对乳房炎的治疗具有重要意义。
The single-dose pharmacokinetics of ciprofloxacin hydrochloride in milk from the cows suffered from endometritis were investigated after the intrauterus administration of ciprofloxacin at the dosage of 2.5 g per cow. The concentrations of ciprofloxacin in milk were determined by HPLC with fluoroscence detector method. The study results showed that the drug concentration in the blood was higher than that in the milk from 0 to 24 hours after the intrauterus administration of ciprofloxacin; drug concentration in the milk was higher than that in the blood 24 houres later. The mean drug concentration of ciprofloxacin in milk was higher than MIC value within 48 hours. Therefore, this concentration has the role of inhibiting bacteria and is important for therapy of the mastitis.
出处
《动物医学进展》
CSCD
2008年第2期6-9,共4页
Progress In Veterinary Medicine
基金
十五国家重大科技专项(2002BA518A04)
关键词
盐酸环丙沙星
奶牛
子宫内膜炎
乳腺排泄
ciprofloxacin hydrochloride
cow
endometritis
mammary gland excretion
