摘要
目的评价长春瑞滨与顺铂组成NP和环磷酰胺、吡喃阿霉素及顺铂组成的CAP两种化疗方案治疗晚期非小细胞肺癌的疗效和毒副反应。方法NP方案：长春瑞滨25mg/m^2,d1,8,快速静脉滴注,顺铂80mg/m^2,d2-4,静脉滴注;CAP方案：环磷酰胺600mg/m^2,d1,8,快速静脉滴注,吡喃阿霉素50mg/m^2,快速静脉滴注,顺铂80mg/m^2,d2-4,静脉滴注,两组均用格拉司琼止吐,根据骨髓情况21-28d为1周期,每例至少2周期。结果NP组23例,完全缓解（CR）1例,部分缓解（PR）10例,有效率为47.8%;CAP组22例,完全缓解（CR）0例,部分缓解（PR）9例,有效率为40.9%。两组方案疗效比较,差异无统计学意义（P〉0.05）。两组主要毒副反应为剂量限制性骨髓抑制和胃肠道反应。NP组和CAP组Ⅲ-Ⅳ度白细胞减少分别为21.74%和13.64%（P〈0.05）;恶心呕吐分别为78.26%和95.45%（P〈0.01）。白细胞减少NP组较重,恶心呕吐CAP组较重。结论NP和CAP方案治疗非小细胞肺癌疗效差异无统计学意义,毒副反应可以耐受,都可作为一线化疗方案。
Objective To compare the therapeutic effects and toxicity of the two different chemotherapy protocols for advanced NSCLC. NP groups, novelbine（NVB） puls cisplatin（DDP）. CAP groups, cyclophosphamide（CTX） , pirarubicin（THP） plus cisplatin（DDP）. Methods NP groups ： NVB 25 mg/m^2 i. v infusion in the first and the eighth day, DDP was given at a dose of 80 mg/m^2 in the second, third and fourth day. CAP groups： CTX 600 mg/m^2 i. v infusion in the first and the eighth day, THP 50 mg/m^2 i. v infusion in first day, DDP was used in the same way. Results 23 cases were treated with NP groups. There were 1 CR, 10 PR. The response rate was 47.8%. The CAP groups had 22 patients. The response rate was 40.9% . The difference between the two groups was no statistically significance（ P 〉 0.05 ）. The major toxic reaction in the two groups was bone marrow suppression and nausea/vomiting. Ⅲ/Ⅳ fall white cells were 21.74% , 13.64% （P 〈 0.05 ）. Nausea/vomiting were 78.26% ,95.45% （ P 〈 0.01 ）. Conclusions The protocols（ NP or CAP） were effective for advanced NSCLC with tolerable side effects, they are all considered as the first chemotherapy.
出处
《肿瘤基础与临床》
2008年第1期46-47,共2页
journal of basic and clinical oncology
关键词
非小细胞肺癌
药物治疗
化疗方案
non-small cell lung cancer
drug therapy
chemistry methods
