摘要
目的比较NP(去甲长春花碱、顺铂)和CAP(环磷酰胺、阿霉素、顺铂)联合化疗方案治疗晚期非小细胞肺癌(NSCLC)的近期疗效和毒副反应。方法统计分析72例接受NP或CAP方案联合化疗的晚期非小细胞肺癌患者的疗效和毒副反应,其中NP方案42例,CAP方案30例。结果NP组42例,有效19例,有效率为45.24%,CAP组30例,有效11例,有效率为36.67%,两者疗效无显著差异(P>0.05),两者毒副反应主要为骨髓抑制及恶心呕吐,均可耐受。结论NP和CAP方案治疗非小细胞肺癌疗效肯定,毒副反应可耐受,可作为一线治疗方案。
Objective To observe the clinical effect and toxicity of NP and CAP in the treatment of patients with advanced non small cell lung cancer（ NSCLC）. Methods Among 72 patients, 42 patients were treated with NP, 30 patients were treated with CAP, comparing the effect and toxity of NP and CAP. Results The effective rate of NP was 45.24 96. The effective rate of CAP was 36.6796 . No obvious difference between them was observed （ P 〉 0.05 ）. The major toxic effects were myelosuppress and omiting, but can be tolerated. Conclusion The effect of NP and CAP on non small cell lung cancer（NSCLC） is definite and their toxicity can be tolerated. It can be the first choice in the treatment of patients with advanced non small cell lung cancer（ NSCLC）.
出处
《实用药物与临床》
CAS
2007年第1期14-16,共3页
Practical Pharmacy and Clinical Remedies
关键词
非小细胞肺癌
NP
CAP
Non small cell lung cancer（NSCLC）
NP
CAP
