摘要
目的:研究脑缺血合剂对实验性脑缺血大鼠的影响,探讨其作用机制。方法:采用线栓法制备局灶性脑缺血模型,检测血液流变学、血小板最大聚集率、脑指数、脑组织丙二醛(MDA)及超氧化物歧化酶(SOD)的含量。结果:该药可改善血液流变学,降低血小板最大聚集率、脑指数、MDA含量,提高SOD含量,与模型组比较差异有显著性意义(P<0.05或P<0.01)。结论:该药可改善微循环、减轻脑水肿及清除自由基,对局灶性脑缺血具有保护作用。
Objective： To study the effects of Nqxhj on experimental rats with cerebral ischemia and discuss the mechanism. Method： Focal cerebral ischemia model was established in rats by the method of intraluminal suture occlusion of the middle cerebral artery （MCA） in order to observe the influence of Nqxhj on hemorheology, maximum agglutination of platelet, cerebral index, maleic dialdehyde （MDA） and superoxide dismutase （SOD） content. Results： Nqxhj groups significantly improved the hemorheology and reduced the maximum agglutination of platelet, the cerebral index, the concentration of MDA, and increased markedly the content of SOD compared with the models （P 〈0. 05, P 〈0. 01 ）. Conclusion： Nqxhj has obvious protective effects on experimental cerebral ischemia rats by its improving microcirculation, reducing brain edema and disclearing free radical.
出处
《成都中医药大学学报》
2007年第4期37-40,共4页
Journal of Chengdu University of Traditional Chinese Medicine
基金
华中科技大学科技发展基金资助
