摘要
在无水碳酸钾存在下，N，N-二甲基甲酰胺（DMF）为溶剂，由4-氯苯酚、氯乙酸甲酯和甲胺制备了N-甲基-2-（4-氯苯氧基）乙酰胺。较佳合成工艺条件为：反应温度70℃，反应时间3h，n[2-（4-氯苯氧基）乙酸甲酯]：n（甲胺）=1．0：1．2，收率达80％以上。产物经IR、MS、^1H NMR和元素进行了确定。
N-methyl-2-（4-chlorophenoxy）acetamide was synthesized by the reaction of methylamine and methyl 2-（4-chlorophenoxy）acetate which was prepared from 4-chlorophenol and methyl chloroacetate using N,N-dimethyl formamide （DMF） as organic solvent in the presence of anhydrous potassium carbonate. The effects of feed composition, reaction temperature and reaction time on the yield of N-methyl-2-（4-chlorophenoxy）acetamide were investigated. Under the optimized conditions： reaction temperature 70 ℃, reaction time 3 h, and n [2-（4-chlorophenoxy） melthyl acetate] ： n（methyl amine）=1.0 ： 1.2, the yield of N-methyl-2-（4-chlorophenoxy） acetamide reached up to 80%. The structure of the product was characterized by IR.MS.^1H NMR and elemental analysis.
出处
《精细石油化工》
CAS
CSCD
北大核心
2008年第1期65-67,共3页
Speciality Petrochemicals
基金
上海市教育委员会发展基金(050Z13)。
