摘要
目的总结研究缩血管物质和门脉高压症之间关系的观点。方法收集近年来报道血管紧张素Ⅱ和内皮素与门脉高压症之间关系的文章进行分析总结。结果血管紧张素Ⅱ和内皮素通过肝星状细胞作用影响肝纤维化和门静脉压力。结论血管紧张素Ⅱ和内皮素在门脉高压症的发病中起重要作甩；血管紧张素Ⅱ拮抗剂和内皮素拮抗剂能有效降低门静脉压力，进而改善肝纤维化。
Objective We summarized the views between vasoconstrictors and portal hypertension. Methods Many articles of the Angiotensin Ⅱ and endothelin were revi.ewed. Results The Angiotensin Ⅱ and endothelin influence portal venous pressure, haemodynamics and hepatic fibrosis through the HSC. Conclusions The Angiotensin Ⅱ and endothelin are involved in the pathogenesis of cirrhosis and portal hypertension. The Angiotensin Ⅱ and endothelin receptor antagonist can effectively improve hepatic haemodynamics, accordingly reduce the portal venous pressure in cirrhosis.
出处
《国际外科学杂志》
2008年第2期114-117,共4页
International Journal of Surgery
