摘要
目的:寻找控制门静脉高压发生和发展的方法,降低肝硬化门静脉高压的上消化道出血的发生率。方法:对照组肝硬化20例,在常规药物治疗下采用普奈洛尔治疗;观察组肝硬化22例,在常规药物治疗下加用氯沙坦。结果:经2年的观察,与对照组相比观察组发生上消化道出血及死亡例数减少,但差异无显著性(P>0.05)。多元Cox分析显示年龄肝功能与治疗方法仍是影响再出血的指数;氯沙坦可能优于普奈洛尔预防再出血(ρ<0.05)。另外,观察组出现低血压的副作用增多。结论:氯沙坦预防肝硬化门脉高压致上消化道出血的效果优于或与普奈洛尔相当。
Objective: To search for a method which could control the occurrence and development of portal hypertension and could cut down the incidence rate of upper gastrointestinal bleeding caused by portal hypertension.Method: The control group had twenty cases which in treated with routine drug and propranolol,twenty-two cases were observation group which were treated with routione drug and losartan.Result: The result suggested that the number of occurring upper gastrointestinal bleeding in observation group was less than that of control group,but there were no significant statistical differences between two groups(P>0.05).Multielement Cox analysis displayed that age,liver function and therapy means still were the index number of influencing rebleeding.The curative effect of losartan may surpass the curative effect of propranolol(P<0.05).In addition,The side effect of hypotensive in observeing group increased.Conclusion: The effect of losartan prevent upper gastrointestinal bleeding caused by hepatic cirrhosis surpass,the curative effect of propranolol or the curative effect of losartan and propranolol were equivalent.
出处
《河北医学》
CAS
2007年第3期276-279,共4页
Hebei Medicine
关键词
肝硬化
门脉高压
疗
效
Hepatic cirrhosis
Portal hypertension
Curative effect
