摘要
目的:制备以盐酸普萘洛尔药物树脂复合物为含药片芯的渗透泵控释片。方法:通过单因素考察,以2f相似因子法筛选适宜的辅料。结果:聚氧乙烯PEO(N80)和NaCl被选为主要辅料。结论:药物树脂复合物可压性极差,需要一种黏度大、可压性好的辅料使之成型。通过验证PEO满足实验要求。离子交换树脂所载药物需要一定离子强度才能被交换释放,NaCl作为离子型促渗剂,与非离子型促渗剂相比能更快、更多地释放药物。此外,NaC l还具有补充渗透泵外环境中用于交换药物所消耗的离子的作用,预防患者由于长期服用诱发体内电解质紊乱。
Objective：To design a novel propranolol hydrochloride loaded osmotic pump tablet with core of drug resin complexes. Methods：Similar factors were used to evaluate the difference between dissolution curves. The optimal formulation was obtained according to the investigation of single factor. Results：PEO（N80） and NaCl were chosen from list of excipients. Conclusion ：PEO improved bad compressibility of drug-resin complexes. NaCl was the best osmotic pressure agent in this formulation. It was not only used as a pressure agent, but also provided drug-resin complexes with Na ^＋ to exchange drug and supplement the loss of Na^ ＋.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2008年第2期143-145,156,共4页
Chinese Journal of New Drugs
关键词
盐酸普萘洛尔
药物树脂复合物
渗透泵
聚氧乙烯
氯化钠
propranolol hydrochloride
drug-resin complexes
osmotic pump
polyethylene oxide
NaCl
