摘要
目的以阿替洛尔为模型药物研究单层芯渗透泵片简化的制备方法,并进行处方优化.方法用自行设计的带针冲头压制带孔单层片芯,以乙基纤维素为膜材包衣制备渗透泵片,采用相似因子为指标筛选处方.结果单层芯渗透泵片的片芯处方、包衣膜组成及厚度是影响释药的主要因素.在1.00～1.14 mm,片芯孔径对释药影响不大.结论本制备方法可免去激光打孔过程,制得的阿替洛尔单层芯渗透泵片能24 h匀速释药.
Aim The simplified preparative method and formulation for atenolol monolithic osmotic pump tablets were investigated. Methods The core tablets with an indentation were compressed by the punch with a needle. Osmotic pump tablets were prepared by coating the indented tablets. Similarity factor was used to evaluate formulation of osmotic pump tablets. Results The formulation of core tablets and the composition and thickness of coating membrane showed marked effects on drug release. Orifice size of core tablets in the range of 1.00 - 1.14 mm scarcely affected drug release. Conclusion The preparation of osmotic pump tablets was simplified with the exempting of laser drilling. The atenolol monolithic osmotic pump tablets could deliver drug constantly for 24 h.
出处
《药学学报》
CAS
CSCD
北大核心
2006年第5期457-460,共4页
Acta Pharmaceutica Sinica
基金
教育部科学技术研究重点资助项目(104093).
关键词
阿替洛尔
单层芯渗透泵片
正交设计
控制释放
相似因子
atenolol
monolithic osmotic pump tablet
orthogonal design
controlled release
similarity factor
