摘要
目的：对2厂家生产的淫羊藿配方颗粒中的主要黄酮类成分进行比较。方法：建立反相高效液相色谱法同时测定淫羊藿配方颗粒中5种主要黄酮类成分：淫羊藿苷、朝藿定A、朝藿定B、朝藿定C、宝藿苷Ⅰ的含量。结果：2厂家生产的淫羊藿配方颗粒中朝藿定A的含量较一致，生产厂家A产品中朝藿定B的含量较高；生产厂家B产品中淫羊藿苷、朝藿定C、宝藿苷Ⅰ的含量较高。但按药典规定的药材中淫羊藿苷含量折算，2厂家产品淫羊藿苷的提取转移率均较低，只有25％～38％。结论：建议淫羊藿配方颗粒应进一步完善制备工艺，建立多种成分的含量测定方法，以全面控制淫羊藿配方颗粒的质量。
Objective： To compare the content of the main flavonoids in Yinyanghuo granules from two different manufactories. Method ： An HPLC method was developed to determine the content of icarrin, epimedin A, epimedin B, epimedin C, and baohuoside I. Result： The content of epimedin A was almost the same in both products from different manufactories. The content of epimedin B in the granules from manufactory A was higher than that of the product from manufactory B, whereas the content of icarrin , epimedin C, baohuoside I was lower. The extract rate of icarrin in both two products was very low, only 25% -38%. Conclusion： The prepara- tion of the Yinyanghuo granules should be further improved, and the determination method of multiple constituents should be develop to control the overall quality of the Yinyanghuo granules.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2008年第2期160-163,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(30572372)
