摘要
目的:观察早产儿生后早期(2h内)使用肺表面活性物质(PS)预防早产儿呼吸窘迫综合征(RDS)的疗效。方法:我院出生的58例早产儿,其中治疗组28例于生后2h内气管内滴或注入PS预防早产儿RDS,剂量为100mg/kg,对照组30例常规给予氨茶碱、氨溴索治疗。结果:治疗组仅3例发生RDS,其中1例并发气胸放弃治疗,发生率10.7%,对照组有13例并发RDS,共5例因颅内出血、肺出血、气胸等放弃治疗,发生率43.4%。结论:早产儿早期使用PS可以有效减少及减轻RDS发生率及临床症状,有效提高早产儿存活率,安全性好。
Objective： To observe the effects of early use of the pulmonary surfactant （PS） to prevent 2 hour old premature infants from respiratory distress syndrome （RDS）. Methods：58 premature infants born in our hospital were divided into two groups：28 cases of the treatment group were dripped with PS through air tubes with a dose of 100 mg/kg in comparison with the control group who had the routine treatment of aminophylline. Results： Only 3 cases of RDS were found in the treatment group with an incidence of 10.7 % and only one complication of pneumothorex occurred,for which the treatment was given up. The control group saw 13 cases of RDS with an incidence of 43.4%, among which 5 cases were given up treatment because of a complication of intracranial hemorrhage,lung bleeds or pneumothorax, etc. Conclusions： The use of PS can lower the incidence of RDS and alleviate its clinical symptoms effectively in early days of the premature infant and raise their survival rate. PS is safe in this usage.
出处
《儿科药学杂志》
CAS
2008年第1期42-44,共3页
Journal of Pediatric Pharmacy
关键词
早产儿
呼吸窘迫综合征
肺表面活性物质
Premature infant
Respiratory distress syndrome
Pulmonary surfactant
