摘要
目的观察缺氧诱导因子2（HIF-2）在非小细胞肺癌（NSCLC）组织中的表达，分析其与肿瘤生物学特征的关系。方法免疫组织化学方法检测NSCLC组织HIF-2α的表达。结果50例NSCLC组织中HIF-2α阳性表达显著高于正常肺组织（P〈0．05）；HIF-2α的表达与淋巴结转移及临床分期相关．有淋巴结转移组HIF-2α阳性表达和无淋巴结转移组HIF-2α阳性表达两者差异有显著性意义（P〈0．05），临床分期中Ⅰ、Ⅱ和Ⅲ～Ⅳ期HIF-2α阳性表达三者之间差异具有显著性意义（P〈0．05）；HIF-2α的表达与性别、年龄、肿瘤的大小、分化程度及病理组织类型无明显关系（P〉0．05），和TNM分期及淋巴结转移有关。结论HIF-2α的增强表达与非小细胞肺癌的浸润性发展有密切关系。
Objective To observe the expression of HIF-2α in NSCLC and analyze its relationship with tumor biological feature. Methods The expression of HIF-2α in NSCLC lissues was evaluated by immunohistochemical method. Results The value of IOD of HIF-2α expression in NSCLC significantly higher than that in normal lung tissues（ P 〈 0.05 ）, HIF-2α expression is related to tumor lymph node metastasis and clinical stage, There is significant difference between group with lymph node metastasis and group without lymph node metastasis（ P 〈 0. 05）, There is also significant difference among the HIF-2α expression during clinical stage of Ⅰ , Ⅱ , Ⅲ and Ⅳ （ P 〈 0.05）. HIF-2α expression has no obvious correlation with sex, age, size of tumor, differentiation degree, and pathological types （ p 〉 0. 05）, but it is closely related to TNM stage and lymph node metastasis. Conclusion HIF-2α expression has close relationship with the invasive proceeding of NSCLC.
出处
《医学综述》
2008年第2期318-320,共3页
Medical Recapitulate
关键词
非小细胞肺癌
缺氧诱导因子
免疫组织化学
Nonsmall-cell lung cancer
Hypoxia-inducible factor -2α
Immunohistochemistry
