摘要
目的:比较奎硫平和利培酮对老年男性精神分裂症疗效及安全性。方法:将68例年龄60岁以上的精神分裂症病人,随机分为奎硫平组和利培酮组,进行为期8周的治疗。于治疗前及疗后1、2、4、6、8周末进行阳性和阴性症状量表(PANSS)、不良反应症状量表(TESS)评定及有关实验室检查。结果:治疗结束时,两组PANSS评分较入组时显著减低(P<0.01),临床总有效率:奎硫平组90.3%,利培酮组86.7%,无显著性差异(P>0.05),第2、4周末,阴性症状减分奎硫平组较利培酮组显著。奎硫平组兴奋、激越、体位性低血压的发生率较高。结论:奎硫平和利培酮治疗老年男性精神分裂症均有良好疗效,奎硫平更具选择性。
Objective：To compare the efficacy and safety of quetiapine and risperidone in the treatment of old -men schizophrenia. Methods：A total of 68 old - men with age above 60 schizophrenia were randomized into quetiapine group（ n = 34） and risperidone group（ n = 34） for 8 weeks, Positive And Negative Symptoms Scale （PANSS） and Treatment Emergent Symptom Scale（TESS） and related lab tests were used to measure the efficacy and safety before treatment and the end of l st,2nd,4th,6th and 8th week after treatment. Results： at the end of treatment the scores of PANSS in both treatme,t groups decreased significantly compared with baseline （ P 〈0.01 ）. Total clinical effective rates were 90.3% in quetiapine group and 86.7% in risperidone group, and there was no significant difference between two groups. At end of 2nd,4th week after treatment, the relaxation of Negative Symptoms quetiapine group was significantly more than those in risperidone group. The rate of exciting and low posturing blood - pressure was higher in quetiapine group. Conclusions： quetiapine and risperidone are both effective for treating old - men schizophrenia, quetiapine has more choice.
出处
《中国民康医学》
2008年第1期14-15,46,共3页
Medical Journal of Chinese People’s Health
