摘要
剂量反应关系的本质是毒理学的重要特征,并且它在大多数的毒理学教材中都有详细阐述[1]。对环境污染物的危险度评价是毒理学的重要任务之一。目前危险度评价所面临的主要挑战是数据的外推。管理者将从动物实验得到的结果外推到人,不仅要从老鼠到人,还要从实验动物的高剂量接触外推到人的低剂量暴露。这两种外推都存在着很大的不确定性[2]。为了解决这种外推的不确定性,一种新的剂量反应关系模型——毒物兴奋效应——引起了一些科学学的注意。在环境毒理学和医学毒理学领域,毒物兴奋效应是一个很有争议的概念[3-4]。本综述的主要目的是讨论毒物兴奋效应的定义、发展、重要特征、机制、应用和为何未被广泛接受等一系列问题。
The nature of the dose response is therefore an essential feature of toxicology and is represented in detail in most toxicological texts. And risk assessment of all kinds of environment pollutants is one of the principal tasks of the toxicology. The main challenge facing environmental risk assessment is the extrapolation of data. Regulators must extrapolate results not only from animal toxicity studies, typically from mice and/or rats to humans, but also from the very high doses usually used in animal experiments to the very low doses that are characteristic of human exposure. These two types of extrapolation are steeped in uncertainty. To solve this situation, a new dose- response-hormesis -attracted some scientists＇ attention, but the concept of hormesis has highly controversial implications in the areas of environmental and medical toxicology In this review, the of the discussion is primarily on the definition, the development, characteristics, mechanism, implications of the hormesis and why it wasn＇ t accepted by modem biology field, et al.
出处
《中山大学研究生学刊（自然科学与医学版）》
2007年第4期24-34,共11页
Journal of the Graduates Sun YAT-SEN University(Natural Sciences.Medicine)
