摘要
谷胱甘肽是细胞内重要的含ＳＨ基的非蛋白分子，它对氧自由基、有机氢过氧化物以及亲电子剂的灭活起着极重要的作用。但近年来的研究表明，一些连位二卤烷烃、卤烯烃、含酮结构的化合物以及一些异氰酸酯、异硫氰酸酯、醛、α，β－不饱和醛等与谷胱甘肽轭合后可导致毒性代谢物的形成。
Glutathione is the major nonprotein sulfhydrylpresent in cells and plays an important role inthe deactivation of oxygen radicals, organichydroperoxides and electrophiles. However,recent studies show that conjugation of glu-tathione with some vicinal dihaloalkanes,haloalkenes. quinoid compounds, isocyanates,isothiocyanates aldehydes α, β-unsaturatedaldehydes etc. will lead to the formation oftoxic metabolites.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1994年第5期395-399,共5页
Progress In Biochemistry and Biophysics
关键词
谷胱甘肽
解毒作用
毒性代谢物
glutathione. glutathione peroxi-dase. glutathione S-transferase. detoxication.toxic metabolites
