摘要
探讨二氢吡啶类钙通道阻滞剂２，６－二甲基－４－（３－硝基苯基）－１，４－二氢－３，５－吡啶二羧酸－３－甲酯－５－戊酯（ＭＮ９２０２）对小肠缺血再灌注损伤所致休克的保护作用．家兔用无创伤动脉夹夹闭肠系膜上动脉６０ｍｉｎ后松夹，复制小肠缺血再灌注模型．在肠缺血４５ｍｉｎ后ｉｖＭＮ９２０２１μｇ·ｋｇ－１能部分提高血压水平，延缓左室内压和±ｄｐ／ｄｔｍａｘ的降低，减少肌酸激酶和乳酸脱氢酶的释放，使家兔存活时间明显延长（１４２±５０ｍｉｎｖｓ９２±４８ｍｉｎ，Ｐ＜０．０５），２ｈ存活率明显提高（７／１０ｖｓ２／１０，Ｐ＜０．０５）．结果表明ＭＮ９２０２能减轻小肠缺血再灌注引起的休克，改善心脏功能可能是药物的保护作用之一．
The protection of methyl pentyl 1,4 dihydro 2,6 dimethyl 4 (3 nitrophenyl) 3,5 pyridinedicarboxylate(MN9202) on shock induced by intestinal ischemia reperfusion injury in rabbits was investigated. Intestinal ischemia reperfusion model was prepared by clamping superior mesenteric artery for a 60 min period and then relaxing the arterial clamp. MN9202 1 μg·kg 1 was administered intravenously 45 min after intestinal ischemia. MN9202 could partially decrease blood creatine kinase and lactic dehydrogenase level, enhance the recovery of blood pressure, left ventricular systolic pressure, ±dp/dt max , prolong survival time(142±50 min vs 92±48 min, P<0.05) and improve survival rate at 2 h (7/10 vs 2/10,P<0.05). These results indicate that MN9202 attenuates intestinal ischemia reperfusion injury induced shock.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1997年第3期190-193,共4页
Chinese Journal of Pharmacology and Toxicology
关键词
钙通道阻滞剂
戊酯
休克
再灌注损伤
小肠
calcium channel blockers
methyl pentyl 1
4 dihydro 2
6 dimethyl 4 (3 nitrophenyl) 3
5 pyridinedicarboxylate
shock
reperfusion injury
hemodynamics
intestine
