摘要
通过三步反应合成乙氧基胺盐酸盐,采用盐酸羟胺和丙酮反应制备丙酮肟,经硫酸二乙酯乙基化、盐酸水解合成乙氧基胺盐酸盐。实验考察了反应温度、催化剂量、反应时间对乙基化反应的影响。结果表明:在无催化剂条件下,25℃下反应6 h,O-乙基丙酮肟收率87.6%(以丙酮肟计),产品总收率为66.7%(以盐酸羟胺计)。
Ethylamine hydrochloride as pesticide and pharmaceutical intermediates was synthesized through three step reactions. Hydroxylamine hydrochloride was contacted with acetone to give acetoxime then acetoxime was alkylated by diethyl sulfate to form O-ethylacetoxime, and finally, O-ethylacetoxime was hydrolyzed by hydrochloric acid to obtain ethylamine hydrochloride. The process of the reaction was optimized as follow ： acetoxime reacted with diethyl sulfate for 6 h at 25℃ without catalyst to give O-ethylacetoxime with 87.6% of yield baseed on acetoxime. The total yield of product was 66.7% based on hydroxylamine hydrochloride.
出处
《精细化工中间体》
CAS
2007年第6期17-18,21,共3页
Fine Chemical Intermediates
