摘要
目的对在本中心接受双侧脑深部电刺激(DBS)手术3年以上的原发性帕金森病(PD)患者进行随访并分析其治疗效果。方法对2003年以前接受双侧DBS手术的32例PD患者分别在手术后3、12、36个月进行随访,结合是否同时服用左旋多巴进行综合评估,同时对手术并发症进行统计分析。结果32例中1例术后出血,2例患者经过二次手术调整电极位置,其它并发症包括眼肌痉挛、体重增加、发音障碍、肌肉痉挛;手术3年后帕金森病统一评分(UPDRS)改善率分别为48.7%(不用药)、50.6%(用药);左旋多巴用药量减少46%。结论本组资料的手术并发症发生率为15.6%,大部分可以通过手术或调整电极参数解决,DBS对PD患者运动功能的改善作用在3年之后依然显著。
Objective This study provides a 3 year follow-up of deep brain stimulation （DBS） for patients suffered from Parkinsong disease （PD）. Methods Thirty-two patients of PD treated with bilateral subthalamic nucleus （STN） stimulation were assessed 3, 12, and 36 months after surgery. Parkinsonian motor disability was evaluated with and without levedopa treatment, with and without STN stimulation. And complications of surgery were analyzed simultaneously. Results One patient suffered from postoperative hemorrhage. Two patients underwent surgery of replacing electrode. Other complications included eyelid opening apraxia, weight gain and dyskinesias. Parkinsonian motor disability （Unified Parkinson＇s Disease Rating Scale, UPDRS） was improved by 48.7% （＂off＂ drug） and 50. 6% （＂ on＂ drug） three years after STN stimulation. Conclusion Despite high incidence rate of complications （ 15.6% ）, many of them can be solved by adjusting the placement of electrode or the parameter of stimulation, and the marked improvement in motor function is observed 3 years after operation.
出处
《中华神经外科疾病研究杂志》
CAS
2007年第6期506-508,共3页
Chinese Journal of Neurosurgical Disease Research
关键词
帕金森病
随访
脑深部电刺激
并发症
Parkinson＇s disease
Follow up
Deep brain stimulation
Complication
