摘要
目的:优选岗松挥发油β-环糊精包合物的制备工艺。方法:以岗松挥发油与β-环糊精的投料比、包合温度、搅拌时间为3个因素,以包合物挥发油的利用率为筛选指标,采用正交试验进行优选。结果:岗松挥发油β-环糊精包合物制备的最佳工艺条件:岗松挥发油与β-环糊精的投料比为1∶10、包合温度为50℃、包合时间为2h。在此条件下,岗松挥发油的平均利用率为81.90%。结论:岗松挥发油β-环糊精包合物的制备工艺切实可行,对提高岗松挥发油制剂的稳定性有一定的参考价值。
OBJECTIVE： To optimize the preparation technology of Oleum Baeckeae oil - β - cyclodextrin inclusion complex. METHODS： The preparation technology for Oleum Baeckeae oil-β- cyclodextrin inclusion complex was optimized by orthogonal experiment taking the ratio of the Oleum Baeckeaee oil to β- cyclodextrin, the temperature for clathration and the duration of stirring as three factors and with the utilization ratio of the essential oil in Oleum Baeckeae oil inclusion complex as index. RESULTS： The optimal technological condition was as follows： the ratio of the Oleum Baeckeae oil to β - cyclodextrin in the inclusion complex was 1 ： 10; the temperature for clathration was 50℃ , and the duration of stirring was 2 hours. Under this condition, the average utilization ratio of Oleum Baeckeae oil was as high as 81.90%. CONCLUSION： The optimized preparation technology of Oleum Baeckeae oil - β- cyclodextrin inclusion complex is feasible and serves as reference for the enhancing of stability of Oleum Baeckeae oil preparation.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第36期2830-2832,共3页
China Pharmacy
关键词
岗松挥发油
Β-环糊精
包合物
正交试验
制备工艺
Oleum Baeckeae oil
β - cyclodextrin
Inclusion complex
Orthogonal experiment
Preparation technology
