摘要
以正常人外周静脉血淋巴细胞为标准二倍体细胞，以吖啶橙为细胞DNA荧光探针，用阿达玛变换显微图象分析仪测定了六例乳腺肿瘤的细胞DNA含量（倍性），分析结果与病例学诊断结论吻合，表明该仪器可望用于乳腺癌的诊断和预后研究．研究结果还表明：乳腺肿瘤细胞DNA倍性与核面积（象素）呈显著正相关．
Normal human lymphocyte was used as standard diploid cell, acridine orange was used as fluorescence probe for DNA in cell, and DNA ploidy of six cases of human breast tumor was analyzed by the system of Hadamard transform microscopic image analysis. Some parameters were employed to evaluate tumor malignancy, the results are concordant with pathological diagnosis, this indicates that the above instrument may be applied in diagnostic and prognostic study on human breast cancer. The results also show that significant positive correlation exists between tumor cell nuclear DNA ploidy and its area (pixels).
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1997年第2期216-219,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
湖北省自然科学基金
