摘要
1994年6月随机抽取了全部出院(包括死亡)病案1312份,其中医院内感染124例,168例次.对此124例医院感染应用抗生素情况进行临床评价.评价标准按我们课题组制订的标准进行.医院感染最常见的部位主要是下呼吸道感染59例次(35.12%)、泌尿道感染20例次(12.50%)、胃肠道感染19例次(11.31%)和上呼吸道感染19例次(11.31%).医院感染124例总共培养出致病菌89株.124例医院感染共应用抗生素572个疗程,3981天.抗生素应用合理的237个疗程(占41.44%);应用基本合理的154个疗程(占29.62%);应用不合理的181个疗程(31.64%).应用不合理的主要原因是无应用抗生素的适应证(52.17%)和给药时间太长(28.80%).结论是合理应用抗生素首先应强调要严格掌握使用抗生素的适应证.当前提高抗生素合理应用水平,必须加强管理力度.
One hundred twenty-four patients with nosocomial infections (NI) selected from 1312 patients hospitalized in June 1994 were studied. The use of antibiotics in the 124 cases of NI were evaluated a-gainst a self-set standard. The most common sites of NI were lower respiratory tract (59 times, 35-12%), urinary tract(20 times, 12-50%), gastrointestinal tract(19 times, 11.31%)and upper respiratory tract(19 times, 11. 31%) in the 124 NI patients with total infection times being 68 times. 89 strains of bacteria were i-dentified by cultures in 124 patients with NI. in 572 therapeutic courses (3981 days) of antibiotics received by the 124 patients with NI, 237(41.44%) courses were judged to be appropriate; 154(26.92%) to be fairly appropriate and 181(31.64%) to be inappropriate. The inappropriate use included use of antibiotics for patients without indication (52.17%) and over-protracted use (28.80%). It is concluded that appropriate use of antibiotics lies in the strict identification of indications for antibiotic therapy. The regulations on the use of antibiotics has to be toughened.
出处
《药物流行病学杂志》
CAS
1997年第3期161-164,共4页
Chinese Journal of Pharmacoepidemiology
关键词
抗生素
医院内感染
Antibiotic
Indication
Inappropriate use
Nosocomial infection
The assessment standard
