摘要
目的：评价5种不同摩尔比的聚丙交酯／乙交酯（PLGA）胆道支架在体外人胆汁中的降解规律及其径向支撑力的变化规律．方法：取5种比例（90L／10G，80L／20G，70L／30G．60L／40G．50L／50G）的PLGA支架各32个，每一比例分成8组，分别浸泡于装有新鲜人胆汁的试管中并置于37％恒温震荡器．每周观察支架的大体形态，测量其质量和径向支撑力。扫描电镜观察支架表面形态．结果：①支架的降解时间随丙交酯含量的减少而缩短，其降解高峰依次为35～42d，28—35d，21—28d，14～18d和8—15d；②支架的径向支撑力随丙交酯含量的减少而降低，其能够在胆道中维持支撑的时间分别为5，4，3，2和1wk．结论：PLGA材料具有可调节的生物降解性和良好的力学特性，适宜制成胆道支架．
AIM： To evaluate the biodegradation law and the change in radical force of 5 different mole-ratios of biliary stents made of poly （lactic-co-glycolic acid） （PLGA） in human bile in vitro. METHODS： Thirty-two PLGA biliary stents of 5 different mole-ratios （90L/10G, 80L/20G, 70L/30G, 60L/40G, 50L/ 50G） were respectively divided into 8 groups. All of them were independently submerged into shaking test tubes with fresh human bile and incubated at 37℃. Their shapes were observed and their weights and radical forces were measured every week. The surfaces were observed by scanning electron microscope. RESULTS： （1） With the content of PLA decreasing, the degradation time of the stent became shorter. The degradation peak times of 5 different mass-ratios of biliary stents were 35 - 42 d, 28 - 35 d, 21 -28 d, 14 - 18 d and 8 - 15 d, respectively; （2） With the content of PLA decreasing, the radical force of the stent became weaker. The times for which 5 different mass-ratios of biliary stents could sustain the support in the bile duct were 5, 4, 3, 2 and 1 wk, respectively. CONCLUSION： PLGA material has adjustable biodegradation and good mechanical properties, so it is suitable for preparation of biliary stent.
出处
《第四军医大学学报》
CAS
北大核心
2007年第23期2138-2140,共3页
Journal of the Fourth Military Medical University
基金
西安交通大学第一附属医院院基金(2006YK6)
关键词
聚丙交酯
生物降解
力学特性
胆道支架
poly
biodegradation
mechanical characteristics
biliary stent
