摘要
将聚乳酸(polylactic acid,PLA)编织线经手工编织成环形网状结构血管内支架,冠峰连接处分别采用聚己内酯(poly-caprolactone,PCL)管封套黏结和4014医用胶水黏结.通过测试两种支架的扩张性能、黏结点牢度、径向压缩性能及体外降解性能,探讨黏结点工艺对血管内支架生物力学性能的影响.试验结果表明:PCL管封套黏结的PLA血管内支架的黏结点牢度与压缩回复率较高,且扩张性较好,但径向压缩力较低,径向压缩性能及体外降解性能与4014医用胶水黏结的PLA血管内支架相似,PCL管封套黏结的PLA血管内支架更适用于临床.
A hand-made biodegradable intravascular stent with zig-zag structure was developed, which is made from polylactic acid （PLA） braided thread. Two kinds of PLA intravascular stent were prepared, and the crown peak adhesion of them was achieved by poly-caprolactone （PCL） tube and 4014 medical glue respectively. To study the influence of adhesion method on the mechanical properties of intravascular stent, expansion property, fastness of adhesion point, radial compression property and in vitro degradation were tested. The experimental results showed that the PLA intravascular stent with PCL tube adhesion had higher fastness and better expansion uniformity as well as higher radial compression recovery rate, but lower radial compression strength. Both stents had similar trend of radial compression performance in vitro degradation. PLA intravascular stent with PCL tube adhesion was more suitable for clinic.
出处
《东华大学学报（自然科学版）》
CAS
CSCD
北大核心
2015年第6期743-749,共7页
Journal of Donghua University(Natural Science)
基金
上海市科委资助项目(10411953300)
高等学校学科创新引智计划资助项目(B07024)
关键词
聚乳酸(PLA)
血管内支架
黏结点
力学性能
polylactic acid （PLA）
intravascular stent
adhesion point
mechanical property
