摘要
心血管并发症如冠状动脉粥样硬化、心肌梗死和中风等是糖尿病患者致残和致死的主要原因之一。动物模型和临床研究均显示氧化应激加速了糖尿病心血管并发症的发生发展过程。活性氧可以通过多种机制产生,糖尿病患者的糖代谢和脂代谢紊乱能诱发活性氧的生成增多,引起氧化应激,最终导致糖尿病心血管并发症的发生。
Most diabetes-related deaths are due to cardiovascular complications, such as atherosclerosis, myocardial infarction, and stroke etc. Oxidative stress has been found in animal models as well as in patients with diabetes and has been suggested as a possible contributor to the accelerated cardiovascular complications in diabetics. The reactive oxygen species in the patients with diabetes are generated via several mechanisms and is initiated not only by glucose, but also by other substances found in diabetic patients. The resulting oxidative stress eventually leads to the development of cardiovascular complications.
出处
《医学分子生物学杂志》
CAS
CSCD
2007年第6期537-540,共4页
Journal of Medical Molecular Biology
基金
国家重点基础研究发展规划项目(973计划)(No.2006CB503903)
国家自然科学基金(No.30440065
30572082)
北京市自然科学基金(No.7052059)~~
关键词
糖尿病
心血管并发症
氧化应激反应
diabetes
cardiovascular complications
oxidative stress
