摘要
目的探讨2型糖尿病(DM)患者内皮细胞功能改变及其临床意义。方法应用ELISA发及发色底物法测定DM患者血中血管性血友病因子(vWF)、6-酮-前列腺素F1a。(6-K-PGFla。)含量及纤溶酶原激活物抑制剂l(PAI-1)活性。结果①糖尿病组vWF、6-K-PGFla、PAl-1的测定结果均较正常对照组有显著性改变(p<0.05或P<0.01),其中vWF、PAI-1表现为增高,6-K-PGFla表现为降低。②DM有并发症组与DM无并发症组相比较,vWF、6-K-PGFIa、PAI-1各指标间亦有显著性差异(p<0.05或p<0.01)。③各指标改变的幅度随病变的程度而加重。结论通过测定反映血管内皮损伤等血栓前状态几个方面的指标,不仅有助于深入了解糖尿病血管损伤的并发症及血栓形成的发生机制,而且为临床上对糖尿病病人使用抗凝剂及抗血小板药物治疗提供了理论依据。
Objective To explore the changes and climncal significance of plasma von willebrandvWF)、6-K-PGFl a and plasminogen activator inhibitor-1PAL-l)levels in patients with type 2 diabetes mellitus.Methods Plasma vWF、6-K-PGFl a and PAL-l were measured by ELISA and chromogenic assay respectively in 35 normal control group、56patients with type 2diabetes mellitus.Results In DM group plasma levels of vWF and PAL-l were significantly higher than those of control group and 6-K-PGFl a levels was significantly lower than that of control group.There was a signincant difference between DM group without complition and DM with complication.Conclusions There were endothelial damages in patients with type 2 diabetes mellitus.The levels of plasma vWF、6-K-PGFl a and PAL-l may be used to surveillance the type 2 diabetes mellitus.It is important for the diagnosis and therapy of high coagulation state in DM patlents.
出处
《医学检验与临床》
2006年第1期54-55,共2页
Medical Laboratory Science and Clinics
