摘要
近年来,随着血栓和止血研究的深入,各类新型抗凝药物不断涌现。本文就直接凝血酶抑制剂、FⅦa/TF复合物抑制剂和FXa抑制剂三类药物的作用机制、实验室监测、临床疗效以及毒副作用等作一综述。
出处
《国际输血及血液学杂志》
CAS
2007年第6期513-516,共4页
International Journal of Blood Transfusion and Hematology
参考文献19
-
1Knoderer CA, Knoderer HM, Turrentine MW, et al. Lepirudin anticoagulation for heparin induced thrombocytopenia after cardiac surgery in a pediatric patient. Pharmacotherapy, 2006,26 (5) : 709- 712. 被引量:1
-
2Keeling D, Davidson S, Watson H, et al. The management of heparin induced t hrombocytopenia. Br J Haematol, 2006,135 (2) : 269. 被引量:1
-
3Choudhury A, Goyal D, Goyal D. Ximelagatran. Drugs Today (Barc). 2006,42(1):3-19. 被引量:1
-
4Feissinger JN, Huisman MV, Davidson BL, et al. Ximelagatran vs low-molecular-weight heparin and warfarin for the treatment of deep vein thrombosis: a randomized trial. JAMA, 2005,293(6) : 681-689. 被引量:1
-
5Diener HC. Executive Steering Committee on behalf of the SPORTIFF V and V Investigators. Stroke prevention using the oral direct thrombin inhibitor ximelagatran in patients with non-valvular atrial fibrillation. Pooled analysis from the SPORTIF Ⅲ and V studies. Cerebrovasc Dis, 2006,21(4):279-293. 被引量:1
-
6Evans HC, Perry CM, Faulds D. Ximelagatran/Melagatran: a review of its use in the prevention of venous thromboembolism in orthopaedic surgery. Drugs,2004,64(6) :649-678. 被引量:1
-
7Eriksson BI, Dahl OE, Buller HR, et al. A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO Ⅱ randomized trial. J Thromb Haemost,2005,3(1) : 103-111. 被引量:1
-
8Bergum PW, Cruikshank A, Maki SL, et al. Role of zymogen and activated factor X as scaffolds for the inhibition of the blood coagulation factor Ⅶ a-tissue factor complex by recombinant nematode anticoagulant protein c2. J Biol Chem, 2001,276 (13) : 10063-10071. 被引量:1
-
9Lee A, Agnelli G, Buller H, et al. Dose response study of recombinant factor Ⅶ a/tissue factor inhibitor recombinantnematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement. Circulation,2001, 104(1) :74-78. 被引量:1
-
10Geerts WH, Heit JA, Clagett GP, et al. Prevention of venous thromboembolism. Chest,2001, 119(1 supply) : 132S-175S. 被引量:1
同被引文献16
-
1陈蓉,谢梅林.新型抗血栓药物作用机制研究进展[J].中国药理学通报,2004,20(8):857-860. 被引量:6
-
2王海萍,王健伟,韩金祥,贾友苏,洪涛.因子Ⅹa抑制剂研究进展[J].生物技术通讯,2004,15(5):495-497. 被引量:3
-
3PINTO JP D,ORWAT JM,KOCH S,et al. Discovery of 1-(4-methoxyphenyl ) -7-oxo-6-( d-( 2-oxopiperidin-1-yl ) phenyl )-4,5,6, 7-tetrahydro-1 H-pyrazolo [ 3,4-c] pyridine-3 -carboxamide ( apixa- ban, BMS-562247 ) , a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa [ J ]. J Med Chem,2007,50 ( 22 ) : 5339 - 5356. 被引量:1
-
4MEDERSKI WKR W, DORSCH D, ANZALI S, et al. Halothio phenebenzimidazoles as P1 surrogates of inhibitors of blood coagu lation factor Xa [J]. Bioorg Med Chem Lett, 2004, 14 (14) 3763 - 3769. 被引量:1
-
5ROEHRIG S,STRAUB A,POHLMANN J,et al. Discovery of the novel antithrombotic agent 5-chloro-N-(1 ( 5S ) -2-oxo-3-[ 4-( 3- oxomorpholin-4-yl) phenyl ] -1, 3-oxazolidin-5-yl I methyl ) thiophene-2-carboxamide(BAY59-7939) : an oral, direct factor Xa inhibitor[J]. J Med Chem ,2005,48 ( 19 ) :5900 - 5908. 被引量:1
-
6拜尔公司.取代的噁唑烷酮和其在血液凝固领域中的应用:德国,CN00818966.8[P].2003-08-06. 被引量:1
-
7高亚玥,王书杰.抗血栓药物的研究进展[J].中日友好医院学报,2009,23(4):250-253. 被引量:12
-
8陈怡琳,施仲伟.抗凝新药利伐沙班临床研究进展[J].心血管病学进展,2009,30(5):810-813. 被引量:30
-
9田国祥,魏万林,张灵.后华法林时代口服抗凝新秀:达比加群、利伐沙班、阿哌沙班[J].中国循证心血管医学杂志,2011,3(5):403-406. 被引量:23
-
10杨银萍,王红波,马庆文.利伐沙班的合成工艺改进[J].中国药物化学杂志,2013,23(1):26-29. 被引量:5
引证文献2
-
1袁静,黄长江,张俊伟,张士俊,徐为人.利伐沙班的合成[J].中国新药杂志,2010,19(23):2185-2187. 被引量:18
-
2尹秀娥,胡小燕,侯德粉,张嘉月,董乔.利伐沙班有关物质的HPLC测定[J].中国医药工业杂志,2019,50(12):1487-1491. 被引量:4
二级引证文献22
-
1高扬,梁斌,倪国伟,王环,张福利.利伐沙班合成路线图解[J].中国新药杂志,2012,21(4):371-374. 被引量:8
-
2符利梅,蒋翔锐,沈敬山,赵波.利伐沙班合成路线图解[J].中国医药导报,2012,9(13):112-113. 被引量:1
-
3谭祖磊.抗凝血药利伐沙班合成研究进展[J].中国医药技术经济与管理,2012(6):56-59. 被引量:1
-
4杨银萍,王红波,马庆文.利伐沙班的合成工艺改进[J].中国药物化学杂志,2013,23(1):26-29. 被引量:5
-
5吴翔,高伟雪,田果,薛松.利伐沙班中间体4-(4-氨基苯基)-3-吗啉酮的合成[J].天津理工大学学报,2013,29(3):42-44.
-
6袁利杰,刘辉,杨本霞,郑子栋.HPLC法测定利伐沙班片的含量和有关物质[J].药物分析杂志,2015,35(4):699-704. 被引量:7
-
7刘超逸,张戈,杭太俊,王磊,张晓飞,宋敏.LC-MS法鉴定利伐沙班有关物质[J].中国药科大学学报,2015,46(4):450-457. 被引量:2
-
8李维思,徐强,王华,陈涛.利伐沙班异构体杂质的合成[J].山东化工,2016,45(10):34-36. 被引量:1
-
9郭军霞.抗凝药物利伐沙班合成技术的专利综述与分析[J].化工管理,2017(13):37-38. 被引量:1
-
10熊刚,冯菊红,李云龙,胡佳,武磊,胡学雷.利伐沙班关键中间体4-(4-氨基苯基)-3-吗啉酮的合成工艺改进[J].化学与生物工程,2017,34(5):50-52.
-
1符坚,朱小华,李强,陈国华.利伐沙班合成工艺改进[J].安徽医药,2013,17(6):917-918. 被引量:2
-
2熊长明.新型抗凝药的研究进展和临床应用[J].中国新药杂志,2009,18(17):1618-1622. 被引量:4
-
3黄海彬,卢晓霞,邱倩倩,邓欣,张文婕.抗凝药物临床应用的研究进展[J].海峡药学,2013,25(6):1-4. 被引量:7
-
4缪京莉,刘颖萍,刘波.血栓形成及抗凝药物在临床应用中的思考[J].医学与哲学(B),2012,33(3):44-45.
-
5阎小青.抗凝药物的临床应用现状[J].天津药学,2014,26(6):48-50. 被引量:5
-
6袁静,黄长江,张俊伟,张士俊,徐为人.利伐沙班的合成[J].中国新药杂志,2010,19(23):2185-2187. 被引量:18
-
7李焰生.预防心源性卒中的新型抗凝药物[J].中国新药杂志,2011,20(11):981-984. 被引量:2
-
8余和平.抗凝药物研究进展[J].中国医师进修杂志(内科版),2009,32(4):72-74. 被引量:3
-
9黄胜炎(摘).国外新批准上市的药物新制剂新剂型(127)[J].中国制药信息,2008,24(7):10-12.
-
10罗鹃.凝血酶直接抑制剂——比伐卢定[J].中国药学杂志,2002,37(10):780-790. 被引量:6