摘要
利伐沙班是一种新型可直接口服的抗凝血剂.本文以乙醇胺、溴代苯和氯乙酸乙酯为主要原料,合成利伐沙班的关键中间体4-(4-氨基苯基)-3-吗啉酮.该方法反应所需原料易买,反应条件温和,反应步骤短,产率较高.
Rivaroxaban is a novel oral anticoagulant.Synthesis of 4-（4-aminophen-yl）-3-morpholinone from 1-bromobenzene,2-aminoethanol,and ethyl 2-chloroacetate is described.The target compound is a key intermediate for preparation of Rivaroxaban.The procedure involved in available starting materials and short reaction steps shows high yield under mild conditions.
出处
《天津理工大学学报》
2013年第3期42-44,共3页
Journal of Tianjin University of Technology
基金
国家自然科学基金(21072152)
