摘要
对16例口腔粘膜原发性恶性黑色素瘤进行了临床病理及免疫组织化学分析。结果表现，本组病例占同期全身恶性黑色素瘤的10．2%（16/156）发病年龄30～66岁，平均46．3岁，男女之比为1．29：1。9例（56．3％）于发病前有口腔粘膜黑斑病史。本组发生于牙龈、牙槽粘膜9例（56．3％），上腭部6例（37．5％）。除HE染色外，还进行了S-100蛋白及HMB-45的免疫组织化学染色，阳性率分别为100％和87．5％。应用Giemsa液复染，代替常现的苏木素液复染，使免疫组化染色结果更易判断。本文结合国内外文献对本病的临床病理特点及癌前病变、早期诊断进行了讨论。
Clinicopathlogical and edsthehedcal analysis of l6 cases of primary malignant melanoma of the ond cavity was made.The results shawed Ihat the incidence of oral melanOma was l0.25% (l6/l56)of all the Patients with Inalignan melanoma at the Departrment of Pathlogy, Shandong Provincial Hospital,in the 2o years from 1975 to l995.The age ranged from 30 to 66 yeare old,the aveop op was 46.3years old, the ratio of male to fernale was l .29: l. Melanotic macule of the oral mucosa had presented for a considIable peried of time before melanoma develpment in 9 cases. The Primary sites were Verified gingva(56. 3%,9/l6) and palate(37 .5%,6/l6) were the two most common areas. These cases were stained with LSAB method for immunohistochemical markers of S - l00 Protein and HMB - 45, the posihve rates were l00% and 87.5%,respectiovely. The immunohistochemical results were easily determined using Giemsa soluhon to take the place of hematoxylin for counterstaining.
出处
《河南肿瘤学杂志》
1997年第3期165-167,共3页
Henan Journal of Oncology
关键词
口腔粘膜肿瘤
恶性
黑色素瘤
病理学
免疫组化
oral neoplasms, malignant melanoma, pathology, clinical, immunohistochemistry
