摘要
目的:探讨阻塞性睡眠呼吸暂停综合征(OSAS)患者中与常见心脑并发症可能相关的血清淀粉样蛋白A(SAA)水平的变化。方法:根据睡眠期多导睡眠监测中的呼吸暂停低通气指数(AHI)结果,将62例仅患OSAS的患者分为轻度OSAS组(n=16),中度OSAS组(n=18)和重度OSAS组(n=18)。另选18例健康者作为对照组。以SAA特异性单克隆ELISA法测定和比较各组间上午6:00时的SAA浓度。此外,对OSAS患者作SAA分别与睡眠期AHI和最低脉氧饱和度(miniSpO2)的相关性分析。结果:与正常对照组SAA浓度(9.19±3.87μg/ml)相比,轻度OSAS组即明显增高(13.49±3.08μg/ml,P<0.05),中度及重度OSAS组增高非常显著(18.73±5.29μg/ml和38.56±10.11μg/ml,均为P<0.01)。且OSAS各组间均相差显著,SAA浓度随OSAS程度加重而增高。相关性分析显示OSAS患者SAA浓度与呼吸暂停低通气指数(AHI)间呈显著正相关(r=0.796,P<0.001),与miniSpO2之间呈显著负相关(r=-0.631,P<0.001)。结论:OSAS患者SAA浓度显著增高且与OSAS的严重程度相关。SAA浓度升高可能与OSAS患者心血管和神经元功能异常的高危状态有关。
Objective：To investigate the serum amyloid A （SAA） protein levels possibly associated with the common cardiac and cerebral complications in patients with obstructive sleep apnea syndrome （OSAS）. Methods：Based on apnea hypopnea index（AHI） measured by polysomnography,62 patients with OSAS only were divided into mild OSAS group（n=16） ,moderate OSAS group（n=18） and severe OSAS group（n=18）. Eighteen healthy subjects with matched age and BMI were recruited as control group. SAA specific monoclonal ELISA method was used to measure and compared morning SAA concentrations among different groups. In addition, correlation of SAA with AHI and minimal pulse oxygen saturation （miniSpO2） was analyzed in OSAS patients. Results：Analyzing on SAA concentrations demonstrated that compared with control group（9.19±3.87μg/ml）, SAA levels were significantly higher in mild OSAS group （13.49±3.08 μg/ml,P〈 0.05）,in moderate OSAS group （18.73 ± 5.29 μg/ml, P 〈 0.01）,and in severe OSAS group （38.56 ± 10.11 μg/ml,P 〈 0.01）. There was a significant difference in SAA levels among different groups. As the degrees of OSAS become more severe,SAA level became higher. Analysis indicated that SAA was positively correlated with AHI （r= 0.796,P〈0.001 ）, but negatively correlated with miniSpO2 （r=-0.631 ,P〈0.001 ）. Conclusion：SAA levels were significantly higher in OSAS patients and such an elevation turned to be more remarkahle as degrees of OSAS hecome more severe. Elevated SAA level may contribute to some increased risk for cardiovascular and neuronal dysfunction in OSAS patients.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2007年第11期1257-1260,共4页
Journal of Nanjing Medical University(Natural Sciences)
