期刊文献+

聚乳酸-乙醇酸熔融共聚物的制备与性能研究

Synthesis and characterization of fusing copoly-lactic glycolic acid
下载PDF
导出
摘要 以乳酸(LA)、乙醇酸(GA)为单体,通过直接熔融共聚法合成可生物降解材料聚乳酸-乙醇酸(PLGA)共聚物.研究了聚合时间、催化剂种类、搅拌速度、单体配比等因素对聚合物特性粘数的影响。结果表明:乳酸LA/乙醇酸GA为1:1,反应时间10h,氯化亚锡为催化剂,搅拌速度为200f/min时聚合物特性粘数最大。同时对共聚物的结构和形貌进行了表征。 The lactic acid and glycolic acid, as polymerization monomer, synthesize directly biodegradable PLGA by fuse-polymerization. The paper shows the influence on polymer intrinsic viscosity of polymerization time, catalyst category, mixing speed, monomer ration and so on.. The optimum conditions are: the ratio of LA/GA 1:1, reaction time 10 hours, catalyst stannous chioride, stirred speed 200r/min. Meanwhile, the structure and appearance of copolymer are characterized.
作者 程艳玲 龚平
出处 《功能材料》 EI CAS CSCD 北大核心 2007年第A05期1935-1937,共3页 Journal of Functional Materials
关键词 聚乳酸-乙醇酸 熔融共聚 生物降解 PLGA fuse-polymerization biodegradation
  • 相关文献

参考文献6

二级参考文献50

  • 1熊成东,戴琦,邓先模.聚乳酸-聚丙二醇嵌段共聚物的合成及表征[J].化学通报,1994(5):59-61. 被引量:12
  • 2申有青,张富尧,张一峰,沈之荃.稀土化合物催化内酯开环聚合 Ⅱ.异丙氧基稀土催化D.L-丙交酯开环聚合[J].高分子学报,1995,5(2):222-227. 被引量:25
  • 3[1]Jacobsen S, Fritz H G, Degee P H, et al. Single-step reactive extrusion of PLLA in a corotating twin-screw extruder promoted by 2-ethylhexanoic acid tin(II) salt and triphenylphosphine[J].Polymer,2000,41:3 395-3 403. 被引量:1
  • 4[2]Chu C C. Hydrolytic degradation of polyglycolic acid-tensile strength and crystallinity study[J]. J Appl Polym Sci,1981,26:1 727. 被引量:1
  • 5Zhu K J,Lin X Z,Yang S L.Preparation and properties of D,L-lactide and ethylene oxide copolymer:A modifying biodegradable polymeric material[J].J Polym Sci, Part C:Polym Lett Ed,1986,24(7):331-337. 被引量:1
  • 6Chen X H,McCarthy S P,Gross R A.Synthesis and characterization of L-lactide-ethylene oxide multiblock copolymers[J].Macromolecules,1997,30(15):4295-4301. 被引量:1
  • 7Nagasaki Y,Okada T,Scholz C,et al.The reactive polymeric micelle based on an aldehyde-ended poly(ethylene glycol)/poly(lactide) block copolymer[J].Macromolecules,1998,31(5):1473-1479. 被引量:1
  • 8Zhu K J,Lin X Z,Yang S L.Preparation, characterization, and properties of polylactide (PLA)- poly(ethylene glycol) (PEG) copolymers:A potential drug carrier[J].J Appl Polym Sci,1990,39(1):1-9. 被引量:1
  • 9Huh K M,Bae Y H.Synthesis and characterization of poly(ethylene glycol)/poly(L-lactic acid) alternating multiblock copolymers[J].Polymer,1999,40(22):6147-6155. 被引量:1
  • 10Moon S I,Lee C W,Miyamoto M,et al.Melt polycondensation of L-lactic acid with Sn(Ⅱ) catalysts activated by various proton acids: A direct manufacturing route to high weight poly(L-lactic acid)[J].J Polym Sci, Part A:Polym Chem,2000,38(9):1673-1679. 被引量:1

共引文献226

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部