摘要
目的:测量不同程度膝关节骨关节炎(OA)患者和正常关节软骨的T2弛豫时间并比较其差异性,探讨磁共振T2-mapping成像在OA中的应用价值。方法:48例受检者共66个膝关节分为正常组(n=15)、轻度OA组(n=19)和重度OA组(n=14)。采用4回波SE序列扫描形成T2-mapping,分别测量胫骨内侧髁、外侧髁,股骨内侧髁、外侧髁和髌骨这5处软骨的T2值并对各组间的差异进行统计学分析。结果:正常组5个部位膝关节软骨T2均值为(34.8±1.9)ms～(36.7±1.4)ms;轻度和重度OA组5个部位膝关节软骨的T2均值分别为(42.2±2.3)ms～(44.7±3.5)ms和(44.5±3.0)ms～(46.0±4.0)ms。所有OA患者膝关节周围各处软骨T2弛豫时间均比正常组显著增高(P<0.01),但轻度OA组与重度OA组之间差异没有显著性(P>0.05)。结论:膝关节OA患者关节软骨的T2弛豫时间比正常者明显增加,磁共振T-mapping成像在早期OA的诊断和监测方面具有很高的临床应用价值。
ObjectivetTo measure T2 relaxation time of knee cartilage in patients with varying degrees of knee osteoarthritis （OA） compared with healthy subjects, and to evaluate the clinical value of the T2-mapping imaging in OA. Methods：48 subjects divided to 3 groups,healthy （n= 15） ,mild OA （n=19） and severe OA （n： 14）. A four echo spin-echo was used to form T2-mapping, respectively measure T2 value in five knee cartilage compartments （condylus medialis and condylus lateralis tibiae,condylus medialis and condylus lateralis femoris and patella）. Differences in healthy and mild OA and severe OA groups were analyzed with statistical analysis. Results： Healthy group had mean T2 value of （ 34. 8 ± 1.9） ms- （ 36.7 ± 1.4） ms, while mild OA and severe OA group had mean T2 value of （ 42.2 ± 2.3 ） ms-（ 44.7 ± 3.5） ms and （44.5±3.0）ms- （46.0±4.0）ms. All knee cartilage compartments showed significant （P〈0.01） increases in T2 relaxation time between healthy and OA;however,no significance was found between mild OA and severe OA group （P〉 0.05）. Conclusion：T2 relaxation time of knee cartilage in patients with OA had significant increase compared healthy subjects. MR T2-mapping imaging has a high value in early diagnosis and tracking of OA.
出处
《放射学实践》
2007年第11期1158-1160,共3页
Radiologic Practice
关键词
磁共振成像
软骨
关节
骨关节炎
膝关节
Magnetic resonance imaging
Cartilage, articular
Osteoarthritis
Knee joint
