摘要
将360只1日龄天府肉鸭随机分为6组，分别喂以对照日粮（Cu8mg／kg）和高铜日粮（I组：Cu100mg／kg；Ⅱ组：Cu200mg／kg；Ⅲ组：Cu400mg／kg；IV组：Cu600mg／kg；V组：Cu800mg／kg）6周，研究日粮铜添加水平对雏鸭肝及其相关生化指标的影响。结果显示，Ⅱ组、Ⅲ组、Ⅳ组、V组雏鸭肝出现不同程度的病理损伤，肝细胞颗粒变性、空泡变性。Ⅳ组、V组肝铜含量和血清铜含量均显著高于对照组（P〈0．01）。Ⅲ组、Ⅳ组和V组血清丙氨酸氨基转移酶、天门冬氨酸氨基转移酶活性显著升高（P〈0．01）。结果表明，日粮铜含量达400～800mg／kg即可引起肝的病理损伤。
Effect of high dietary copper intakes on the liver was evaluated in infant ducklings. Duck-lings （60/group） one day of age at the start of dosing were fed a diet containing 8（Control）, 100 （Group I ）,200 （Group Ⅱ ）,400 （Group Ⅲ ）,600 （GroupIV）,or 800 （GroupV） mg/kg per day for 6 weeks. All ducklings were sacrificed at the end of the treatment for pathologic observation and liver functional enzyme levels were determined. Granular and vacuolar hepatocytes were observed in Groups Ⅱ , Ⅲ , IV and V. Liver and serum copper contents in groups IV and V were statistically significantly higher than that in the control group（P〈0.01）. Activities of serum glutamic pyruvic transminase and glutamic oxaloacetic transami-nase in Groups Ⅲ , IV and V were much higher than that in the control group （P〈0.01）. The above results indicated that the duckling liver was damaged when dietary intake of copper in reached 400--800 mg/kg per day.
出处
《中国兽医科学》
CAS
CSCD
北大核心
2007年第11期990-993,共4页
Chinese Veterinary Science
基金
国家自然科学基金资助项目(30471304)
四川省教育厅重点项目(2002A002)
科技厅重点项目(03JY029-030-2)
关键词
雏鸭
高铜
肝
病理变化
生化指标
duckling
high copper
liver
lesions
biochemical index
