期刊文献+

氯吡格雷联合低分子肝素钙治疗进展性脑梗死临床观察 被引量:5

下载PDF
导出
摘要 目的观察氯吡格雷联合低分子肝素钙治疗进展性脑梗死的疗效及安全性。方法将50例急性进展性脑梗死患者随机分为对照组25例和治疗组25例,对照组给予口服氯吡格雷及其他常规治疗,疗程14d;治疗组在对照组治疗基础上加用低分子肝素钙,皮下注射,q12h,疗程10d。观察两组治疗前后神经功能缺损评分(NDS)、血小板(PLT)及凝血功能的变化。结果治疗组显效率高于对照组,差异有显著性意义(P<0.05);治疗后治疗组NDS低于对照组,差异有显著性(P<0.01);治疗组治疗前后PLT及凝血功能均无明显变化;用药过程中均无出血并发症发生。结论氯吡格雷联合低分子肝素治疗进展性脑梗死安全有效。
出处 《现代实用医学》 2007年第10期802-803,共2页 Modern Practical Medicine
  • 相关文献

参考文献7

二级参考文献37

  • 1王学文,王振义.抗凝治疗的进展[J].国外医学(输血及血液学分册),1993,16(1):4-7. 被引量:57
  • 2李晓祥,李耐三.低分子量肝素的抗血栓作用[J].药学进展,1994,18(1):6-10. 被引量:152
  • 3CURE Study Investigators.The Clopidogrel in unstable angina to prevent recurrent events (CURE) trial programme ; rationale,design and baseline characteristics including a metaanalysis of the effects of thienopyridines in vascular disease[J].Eur Heart J,2000,21(24):2033-2041. 被引量:1
  • 4Sabatine MS,Cannon CP,Gibson CM,et al.Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation[J].N Eng J Med,2005,352(12):1179-1189. 被引量:1
  • 5Umesh NK,Steven EN.Is CURE a cure for acute coronary syndromes?statistical versus clinical significance[J].JACC,2002,40(2):218-219. 被引量:1
  • 6Steinhubl SR,Berger PB,Mann III JT,et al.Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention:a randomized controlled trial[J].JAMA,2002,288(19):2411-2420. 被引量:1
  • 7Harrington RA,Becker RC,Ezekowitz M,et al.Antithrombotic therapy for coronary artery disease:the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy[J].Chest,2004,126(3 suppl):513S-548S. 被引量:1
  • 8Bertrand ME,Rupprecht HJ,Urban P,et al.Double-Blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting:the clopidogrel aspirin stent international cooperative study (CLASSICS)[J].Circulation,2000,102(6):624-629. 被引量:1
  • 9Kandzari DE,Berger PB,Kastrati A,et al.Influence of treatment duration with a 600-mg dose of clopidogrel before percutaneous coronary revascularization[J].J Am Coll Cardiol,2004,44(11):2133-2136. 被引量:1
  • 10Adnan K,Nicolas VB,Alexander J,et al.Loading with 600 mg clopidogrel in patients with coronary artery disease with and without chronic clopidogrel therapy[J].Circulation,2004,110(14):1916-1919. 被引量:1

共引文献15827

同被引文献25

引证文献5

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部