摘要
目的:探讨肺癌TNM分期的PET/CT成像表现特点与血清VEGF蛋白表达水平的关系。方法:53例肺癌患者治疗前,对其进行PET/CT检查,再用酶联免疫夹心法检测血清VEGF蛋白的表达水平,分析肺癌的T分期和转移(淋巴结和远处转移)的PET/CT表现特征与血清VEGF表达的关系。结果:经PET/CT成像分析,其中T111例、T29例、T318例、T415例;纵隔淋巴结转移22例,9例患者有远处转移。肺癌患者的血清VEGF表达的平均水平为(378.02±180.79)ng/L,与正常健康人组差异有统计学意义(P<0.05)。在不同的低T分期(T1与T2)患者中,血清VEGF表达水平无显著性差异,而低T分期(T1与T2)患者与高T分期(T3与T4)患者中的血清VEGF表达差异有统计学意义(P<0.05)。纵隔淋巴结转移组血清VEGF表达水平为(561.50±104.55)ng/L,与非淋巴结转移组间比较差异有统计学意义(t=12.21,P<0.05);远处转移组血清VEGF表达水平为(614.11±158.81)ng/L,血清VEGF的表达明显与远处转移相关(t=5.30,P<0.05)。结论:1)肺癌患者血清VEGF水平呈高表达;2)肺癌患者VEGF的表达水平与发生淋巴结转移和远处转移有关;3)随着肺癌TNM分期增加,血清VEGF蛋白表达增强。
Objective： To study the relationship between PET/CT imaging manifestations of the TNM-stages of lung cancer （LC） and the expression of VEGF protein in serum. Methods： Fifty-three LC patients, with PET/CT imaging performed before treatment, were enrolled in this study. The expression of serum VEGF protein was examined by quantitative sandwich enzyme-linked immunosorbent assay（ELISA R＆D system）. A comparison of the PET/CT manifestations of the T-stage and metastasis （lymph nodes and distance） of the lung carcinoma along with the serum VEGF expression was performed. Results： PET/CT imaging manifestations： for T-staging, there were I l patients staged as T1, 9 as T2, 18 as T3, and 15 as T4. In 22 patients there was mediastinal node metastasis. There were 9 patients with distant metastasis. The expression level of serum VEGF in LC patients was 378.02±180.79 ng/l, significantly different from the level seen in normal patients（P〈0.05）. There was no significant difference in the level of serum VEGF between T1 and T2 stage cases, while the expression level of serum VEGF was significantly different between low T-stages（T1, T2） and high T-stages（T3, T4）. The expression level of serum VEGF protein of those with mediastinal node metastasis was 561.50±104.55 ng/l, significantly different from that of patients without metastasis （t=12.21, P〈0.05）. The expression level of serum VEGF of those with distant metastasis was 614.11±158.81 ng/l, significantly different from that of patients without distant metastasis （t=5.30, P〈0.05）. Conclsion： 1） The level of serum VEGF in LC patients was high. 2） There was a correlation between metastasis（lymph nodes and distance） and the expression level of serum VEGF. 3） With increased TNM-stage, the expression level of serum VEGF protein became higher.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2007年第21期1201-1205,共5页
Chinese Journal of Clinical Oncology
基金
湖南省卫生厅科研基金资助(编号:B2005139)
关键词
肺癌
正电子发射断层计算机成像
血管内皮细胞生长因子
肿瘤分期
肿瘤转移
Lung neoplasm Positron emission tomography/Computer tomography Vascular endothelial growth factor Neoplasm staging Neoplasm metastasis
