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基质金属蛋白酶与实验性自身免疫性脑脊髓炎的免疫屏障 被引量：2

Matrix metalloproteinases and the immunological barrier of experimental autoimmune encephalomyelitis
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摘要 实验性自身免疫性脑脊髓炎（experimental autoimmune cncephalomyelitis，EAE）是一种主要由T细胞介导的，以中枢神经系统（CNSl内小血管周围单个核细胞浸润及白质髓鞘脱失为特征的自身免疫性疾病。EAE炎性脱髓鞘的过程有许多重要的炎性细胞因子参与。基质金属蛋白酶（matrix metalloproteinase，MMPs）尤其是MMP-9、MMP-2是引起血脑屏障（blood brain barrier，BBB）的免疫屏障破坏，炎性细胞浸润以及介导细胞外基质（ECM）和髓磷脂降解的重要因素。
作者 魏慧星 吴钢
机构地区 福建医科大学附属第一医院神经内科
出处 《中华神经医学杂志》 CAS CSCD 2007年第11期1183-1185,共3页 Chinese Journal of Neuromedicine
关键词 实验性自身免疫性脑脊髓炎 基质金属蛋白酶-9 基质金属蛋白酶-2 免疫 屏障 炎性因子 Experimental autoimmtme encephalomyelitis MMP-9 MMP-2 Immunological barrier Inflammatory factors
分类号 R744 [医药卫生—神经病学与精神病学]
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参考文献16

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共引文献2

同被引文献17

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引证文献2

二级引证文献14

中华神经医学杂志
2007年 第11期

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