摘要
Th1/Th2型细胞的失衡引起白细胞介素4(IL-4)表达明显上调,并通过IL-4受体而发挥生物效应,诱导T细胞增殖,最终引起了呼吸道慢性非特异性炎症。而IL-4居于细胞因子网络调节中心,增强B细胞表达,促进IgE合成。是调节Th1向Th2细胞分化过程中的惟一重要因子,促进Th2发育分化并抑制Th1细胞功能,为哮喘发病重要机制之一。单味、复方中药、针刺等中医药治疗具有积极调节Th1及Th2细胞的功能,抑制IL-4水平,逆转Th1/Th2失衡的比值,降低炎性介质,抑制呼吸道变应性炎症,降低呼吸道高反应性,达到控制哮喘目的,从而有利于哮喘症状的改善和长期稳定。
The imbalance of Th1/Th2 cause excessive expression of IL-4,which plays biological effects by IL-4 receptor,iuduce T cell proliferation,and then results in chronic respiratory inflammation with non-specificity.IL-4 lies in the regulatory center of cytokine net improving the expression of B cell and promoting synthesis of IgE,which also is the only important cytokine in regulating differentiation from Th1 to Th2.The function promoting developmentof Th2 and inhibiting Th1 is the important pathogenetic mechanism of asthma.Some therapies of TCM including single or multiple herbs and acupuncture have positive effect in regulating Th1 and Th2 cells,which also inhibit IL-4 level,turnover ratio unbanlance of Th1/Th2,decrease inflammatory mediator,inhibit respiratory allergic inflammation,lower respiratory hyperresponsiveness and then achieve the aim of contolling asthma as well as promoting and stabilizing the symptom of asthma in long term.
出处
《医学综述》
2007年第17期1332-1334,共3页
Medical Recapitulate
关键词
白细胞介素4
TH1/TH2失衡
调节
哮喘
中医药疗法
Interleukin-4
Imbalance of Th1/Th2
Asthma
Regulation
Asthma
Traditional chinese medication
