摘要
目的分析输卵管癌的治疗方案和临床病理因素对预后的影响。方法回顾性分析64例原发性输卵管癌的临床资料。结果64例输卵管癌的5年生存率为56.3%,52例接受手术分期患者和12例未接受手术分期患者的3年(84.6%:58.3%)和5年(65.4%:33.3%)生存率比较,差异有统计学意义(P=0.0429,P=0.043)。23例满意细胞减灭术和14例不满意细胞减灭术患者的3年(89.5%:66.7%)和5年(68.4%:41.7%)生存率比较,差异有统计学意义(P=0.0466,P= 0.0444)。41例盆腔淋巴结清扫术和23例无盆腔淋巴结清扫术患者的3年(84.2%:69.2%)和5年(63.1%:53.8%)生存率比较,差异无统计学意义(P=0.4667,P=0.459)。35例CAP方案或CP方案与21例TP方案化疗患者3年(81.8%:80.0%)和5年(59.1%:60.0%)生存率比较,差异无统计学意义(P=0.8946,P=0.9582)。输卵管癌5年生存率与手术病理分期(Ⅲ～Ⅳ期与Ⅰ～Ⅱ期相比,P=0.0197)、病理分级(低分化与高、中分化相比,P=0.003)、组织学类型(非浆液性腺癌与浆液性腺癌相比,P=0.0494)和淋巴结转移(阳性与阴性相比,P=0.0295)有关。结论手术分期、满意的细胞减灭术、病理分级、组织学类型和腹膜后淋巴结转移是影响输卵管癌5年生存率的重要因素。盆腔淋巴结清扫在输卵管癌手术分期和细胞减灭术中是必要和可行的。CAP方案或CP方案以及TP方案均是输卵管癌术后有效的辅助化疗方案。
Objective To investigate the impact of treatment modality and clinicopathologic profile on prognosis in primary fallopian tube carcinoma. Methods The data of 64 cases with primary fallopian tube carcinoma treated between January 1991 and June 2006 were analyzed. The clinicopathological data were retrospectively analyzed. Results The overall 5-year survival rate of this series was 56.3%. The overall 3- and 5-year survival rate was 84.6% and 65.4% in surgical staging group versus 58.3% and 33.3% in no surgical staging group with a significant difference between two groups （ P = 0. 0429 ; P = 0.043）, which was 89.5% and 68.4% in optimal cytoreduction group versus 66.7% and 41.7% in suboptimal cytoreduction group （ P = 0.0466 ; P = 0.0444 ）. However, there was no significant difference in 3-year and 5-year survival rate between the group with pelvic lymphadenectomy and the group without （84.2% vs. 69.2% , P = 0.4667 ; 63.1% vs. 53.8% , P = 0. 459） , and also between the group treated using CAP/CP regimen and the group by TP regimen for chemotherapy （81.8% vs. 80.0% , P = 0. 8946 ; 59.1% vs. 60.0% P=0.9582）. It was found that the 5-year survival was correlated with FIGO stage （Ⅲ-Ⅳ vs. Ⅰ- Ⅱ, P = 0.0197 ） , differentiation grade （ G3 vs. G1 ＋ G2, P = 0. 003） , pathologic type （ other type vs. serous, P =0. 0494）, lymph nodes status （positive vs. negative, P = 0. 0295）. Conclusion Surgical staging, optimal cytoreduction, differentiation grade, pathologic type, lymph node status are important factors influencing the 5-year survival in primary fallopian tube carcinoma. Pelvic lymphadenectomy is necessary and feasible to perform during the procedure of surgical staging and cytoreduction. CAP/CP and TP regiment are similarly effective in adjuvant chemotherapy for primary fallopian tube carcinoma.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2007年第10期789-793,共5页
Chinese Journal of Oncology
关键词
输卵管肿瘤
治疗方案
临床病理因素
预后
Fallopian tube carcinoma
Treatment modality
Clinicopathologic profile
Prognosis
