期刊文献+

雄黄对荷人卵巢癌裸鼠移植瘤细胞凋亡的基础研究 被引量:22

The effect of realgar on apoqtosis of transplanted ovarian SKOV3 carcinoma cells in nude mice
下载PDF
导出
摘要 目的:观察中药雄黄诱导卵巢癌细胞凋亡及血管生成的作用。方法:应用流式细胞术、荧光显微镜、透射电子显微镜和免疫组织化学等技术,以细胞凋亡和VEGF为主要观测指标,观察中药雄黄对荷人卵巢癌裸鼠移植瘤抗肿瘤作用。结果:雄黄可诱导荷人卵巢癌裸鼠移植瘤细胞凋亡,抑制荷瘤裸鼠肿瘤的生长,阻止血管生成抑制细胞DNA的合成,并可延长小鼠存活时间。结论:雄黄可通过诱导卵巢癌细胞凋亡,阻止血管生成,抑制细胞DNA的合成等多种途径发挥抗肿瘤作用,具有广阔的应用前景。 Objective:To observe the effect of traditional Chinese medicine, realgar, on apoptosis and angiogenesis of ovarian carcinoma cells. Methods: The antl-tumor effects of realgar were observed in nude mice bearing ovarian transplanted carcinoma. Apoptosis and the expression of vascular endothelial growth factor were determined by flow cytometry, fluorescence microscopy, transmission electron microscopy, and immunohistochemical methods. Results: Realgar induced apoptosis and inhibited the growth of ovarian transplanted tumors in nude mice. Realgar also blocked the angiogenesis, inhibited the DNA synthesis, and prolonged the survival time of nude mice. Conclusion:Realgar exerted its anti-tumor effect through multiple pathways such as inducing apoptosis, blocking angiogenesis, inhibiting DNA synthesis and had a wide foreground for application.
出处 《肿瘤》 CAS CSCD 北大核心 2007年第10期787-790,共4页 Tumor
基金 河北省科技厅基金资助项目(编号:05276101D-58 06276102D-04)
关键词 卵巢肿瘤 雄黄 抗肿瘤药(中药) 细胞凋亡 Ovarian neoplasms: Realgar Antineoplastic drugs(TCD) Apoptosis
  • 相关文献

参考文献5

  • 1王晓波,张治然,袭荣刚.雄黄等砷剂治疗白血病的机理及临床应用[J].解放军药学学报,2003,19(2):129-132. 被引量:18
  • 2ZHANG L, YANG N, KATSAROS D, et al. The oncogene phosphatidylinositol 3-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma [J]. Cancer Res, 2003,63(14) :4225-4231. 被引量:1
  • 3YABUSHITA H, NOGUCHI M, OBAYASHI Y, et al. Angiostatin expression in ovarian cancer[J]. Oncol Rep, 2003,10(5 ) :1225- 1230. 被引量:1
  • 4GADDUCCI A, VIACAVA P. COSIO S, et al. Vascular endothelial growth factor (VEGF) expression in primary tumors and peritoneal metastases from patients with advanced ovarian carcinoma [J]. Anticancer Res, 2003,23(3C) :3001-3008. 被引量:1
  • 5STADLMANN S, AMBERGER A, POLLHEIMER J, et al. Ovarian carcinoma cells and IL-1 beta-activated human peritoneal mesothelial cells are possible sources of vascular endothelial growth factor in inflammatory and malignant peritoneal effusions[J]. Gynecol Oncol, 2005,97 ( 3 ) : 784-789. 被引量:1

二级参考文献43

共引文献17

同被引文献358

引证文献22

二级引证文献105

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部