摘要
目的:观察血清基质金属蛋白酶-2(MMP-2)及其组织抑制因子(TIMP-2)与慢性乙型肝炎患者肝纤维化程度的相关性.方法:用ELISA方法检测60例慢性乙型肝炎患者的血清MMP-2和TIMP-2的含量,并与20例健康人员作对比,分析二者与患者肝纤维化程度之间的关系.结果:慢性乙型肝炎重度患者血清MMP-2和TIMP-2的水平分别较对照组、慢性乙型肝炎轻、中度升高(P<0.05);而慢性乙型肝炎轻、中度患者的MMP-2和TIMP-2水平与对照组比较无统计学差异(P>0.05).慢性乙型肝炎轻、中度患者的MMP-2,TIMP-2比较无统计学差异(P>0.05).血清MMP-2,TIMP-2水平分别与肝纤维化程度有相关,二者的相关系数r值分别为0.851,0.623,P值均<0.01.结论:患者血清中MMP-2,TIMP-2水平随慢性乙型肝炎病情的加重而升高,并与肝纤维化程度有相关.
AIM： To investigate the relationship of the levels of serum matrix metalloproteinase-2 （MMP-2） and tissue inhibitor of metalloproteinase-2 （TIMP-2） with hepatic fibrosis degree in patients with chronic hepatitis B. METHODS： Serum levels of MMP-2 and TIMP-2 were measured by ELISA in 60 patients with chronic hepatitis C and 20 healthy controls. RESULTS： The serum MMP-2 and TIMP-2 levels were significantly increased in severe chronic hepatitis B, but not in mild and moderate chronic hepatitis B. There was no significant difference in the serum MMP-2 and TIMP-2 levels between the patients with mild and moderate chronic hepatitis. The levels of serum MMP-2 and TIMP-2 showed a positive correlation with the degree of hepatic fibrosis （r = 0.851,0. 623, P 〈 0.01 ）. CONCLUSION： Serum MMP-2 and TIMP-2 levels are significantly increased in chronic hepatitis B and have a good correlation with hepatic fibrosis.
出处
《第四军医大学学报》
北大核心
2007年第20期1865-1867,共3页
Journal of the Fourth Military Medical University
关键词
明胶酶A
金属蛋白酶-2组织抑制剂
肝炎
乙型
慢性
gelatinase A
tissue inhibitor of metalloproteinase-2 （TIMP-2）
hepatitis B, chronic
