摘要
分化型甲状腺癌约有30％肿瘤发生去分化，以致于术后^131I治疗和甲状腺素替代治疗疗效差或无效。维甲酸作为维生素A的生物活性代谢产物，对于多种细胞的发生、增殖、分化起着重要的作用。多项研究发现，维甲酸诱导再分化治疗分化型甲状腺癌的潜力巨大。
About 30% of differentiated thyroid carcinoma （DTC） loses its ability of differentiation, which results in poor or no effect of the radioiodine therapy and the thyroid hormone replacement therapy after operation. Retinoic acids, the biologically active metabolite of vitamin A, is of central importance for growth, proliferation and differentiation of various ceils. In this review, summarized the mechanism of the dedifferentiation among the DTC, the retinoic acids-induced redifferention and the clinical use of retinoic acids. It is demonstrated by many studies that retinoic acids-induced redifferentiaon has a large potential in the treatment of DTC.
出处
《国际放射医学核医学杂志》
2007年第4期221-225,共5页
International Journal of Radiation Medicine and Nuclear Medicine
关键词
分化型甲状腺癌
维甲酸
再分化
Differentiated thyroid carcinoma
Retinoic acids
Redifferentiation
