摘要
目的：探讨1^H-MRS在脑梗死进展中的应用价值。方法：收集45例脑梗死不同进展期的MRI和MRS进行分析。结果：1^H-MRS检测出45例脑梗死发生后脑内NAA,Cr、Cho三种代谢物含量均出现不同程度下降，以NAA下降显著，而且具有显著差异性——超急性期，NAA轻度下降，急性期NAA显著下降，慢性期NAA下降至最低，甚至为零。而Cr和Cho各期下降组间无显著差异性。同时脑梗死发生后脑内会出现异常含量较高的Lac峰，其含量在脑梗死超急性期出现，急性期达高峰，以后随进程中呈逐渐下降，直至消失。依据NAA和Lac峰的变化规律可对脑梗死进行分期：NAA含量轻度下降，出现Lac为超急性期；NAA含量明显下降，出现明显增高的Lac为急性期；NAA和Lac含量均较低为亚急性期；NAA和Lac含量极低，以NAA为著，甚至接近于零时为慢性期。结论：1^H—MRS可提供脑梗死区的代谢变化，对推断脑梗死的病理生理变化、早期诊断、寻找缺血“半影带”以及预后和疗效的判断均有重要作用。
Objective： To discussion the value of 1^H - MRS in the progress of cerebral infarction. Methods： To collect the 45 cases of MR imaging diagnosis and MR spectroscopy analysis of cerebral infarction. Results： Discreased NAA, Cr,Cho, detection of Lac, no obvious change of Cr and Cho were showed in hyperacute stage of cerebral infarction. As time progress, NAA continued to decrease of even disappear;Lac continued to present in acute and subacute stage, and gradually disappear in chronic stage;Cr and Cho also gradually decreased, but the decreased levels of Cho were varied. Conclusion： 1^H - MRS can provide information about metabolic changes that may be useful for prediction of the rapeutic time window of cerebral infarction.
出处
《中国医药导刊》
2007年第5期375-378,共4页
Chinese Journal of Medicinal Guide
关键词
脑梗死
1^H—MRS
代谢
cerebral infarction
MR Spectroscopy
metabolite
