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奥沙利铂联合亚叶酸钙/5-氟脲嘧啶持续泵人治疗晚期胃肠癌的临床观察 被引量:5

The Clinical Observation of Advanced Gastric Cancer and Colon Cancer Patients Treated with Oxaliplatin , Calcium folinate and 5-Fluorouracil combination chemotherapy
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摘要 目的观察奥沙利铂(L—OHP)联合亚叶酸钙(CF)、5-氟脲嘧啶(5-FU)方案对晚期胃肠癌病人的近期疗效。方法26例晚期胃肠癌患者化疗前经锁骨下静脉留置管内给药。L—OHP150mg/m^2,静滴3h,第1天;CF100mg/d,静滴2h,第1—5天;5-FU 1000mg/m^2,微量泵持续泵人,第1—2天,每14d为1个周期。结果全组26例骨髓抑制发生率为57.7%,KI/IV度者仅1例。胃肠道反应主要为口腔粘膜炎与腹泻,发生率为53.8%,无KI/IV度胃肠道反应。结论L—OHP联合CF/5-FU持续泵人治疗晚期胃肠癌的近期疗效较好,药物不良反应低,病人耐受性好,值得推广。 Objective To evaluate the efficacy of oxaliplatin ( L - OHP), calcium folinate (CF) and 5 - fluorouraci] ( 5 - FU) civ combination chemotherapy on advanced gastric/co]on cancer. Methods Twenty - six patients received L- OHP 150 mg/m^2 dr, continue injection (CI) for 3 hours; CF 100rag/d, dt -5, CI for 2 hours and 5 -FU 1 000 rag, dj-2, CI with mini -pump , q2w for 1 cyc]e. Results The main side effects were myelosuppression (57.7%), and nonnasality catarrh and diarrhoea (53. 8% ). Condusion L - OHP, CF and 5 - FU civ chemotharepy regimen is effective in the treatment of advanced gastric/colon cancer, the toxicity is lia- hie to be well tolerated.
作者 谭庆霞
出处 《国际护理学杂志》 2007年第10期1107-1109,共3页 international journal of nursing
关键词 奥沙利铂 亚叶酸钙 5-氟脲嘧啶 化疗 晚期胃癌/大肠癌 护理 Oxaliplatin Calcium foLinate 5 - Fluorouracil Chemotherapy Advanced gastric/Co-lon cancer Nursing care
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