摘要
目的探讨扶芳藤提取物预防给药对大鼠急性脑缺血再灌注后大脑c-fos表达的影响。方法Longa法制作急性脑缺血再灌注损伤模型,用免疫组化法检测脑组织缺血再灌注2、6、12、24 h的c-fos表达水平。结果扶芳藤提取物能降低再灌注2、6、12、24 h后大鼠脑组织中c-fos的表达(P<0.05)。结论扶芳藤提取物对大鼠急性脑缺血再灌注损伤的保护作用机制可能与下调缺血脑组织中c-fos表达有关。
Objective To study the effect of extract of Euonymus fortunei （EE） on the expression of c-fos in cerebral ischemiareperfusion injury rats. Methods The cerebral ischemia-reperfusion model was prepared by means of Longa＇s method. The expression of c-fos were determined by immunohistochemistry. Results The expression of c-fos were decreased in all EE-treated groups after isehemia followed by 2,6,12,24 hours reperfusion. Conclusion The protection of EE to neuronal injury induced by cerebral ischemia-reperfusion may work by downregulating the expression of c-fos.
出处
《广西医学》
CAS
2007年第10期1501-1502,共2页
Guangxi Medical Journal
