摘要
目的评价宫颈上皮内瘤病变与人类乳头状瘤病毒(HPV)感染的关系。方法对该院158例宫颈细胞学异常患者进行阴道镜下宫颈多点活检,同时采用杂交捕获试验法(HC-Ⅱ)进行HPV检测。结果HPV在慢性宫颈炎、非典型鳞状上皮增生、低度鳞状上皮内瘤病变、高度鳞状上皮内瘤病变、宫颈癌的检出率分别为8.7%、34.7%、68.9%、83.3%,其阳性率随病变程度呈趋势性增高(P<0.01)。结论宫颈上皮内瘤病变、宫颈癌与HPV感染密切相关,随着病变程度的加重,HPV检出率增加,提示HPV为宫颈癌的高危因素。宫颈HC-Ⅱ的检测可用于不典型鳞状细胞(ASCUS)、低度鳞状上皮内病变(LSIL)、高度鳞状上皮内病变(HSIL)患者活检前的筛查。
Objective To determine the relationship between cervical cancerous and precancerous lesions and human papilloma virus（HPV） infection. Methods 158 female patients with abnormal pap smears underwent colposcopically directed biopsies and hybrid capture Ⅱ test. Results HPV infection was distributed in 8.7 % of cervitis, in 34.7 % of low-grade squamous intraepithelial lesion（LSIL） ,in 68.9 % of high-grade squamous intraepithelial lesion（HSIL） and in 83.3 % of cervical cancer. Conclusion HPV infection was correlated with cervical（cancerous and intraepithelial neoplasia） lesions and increased with the serious degrees of lesions. Hybrid captureⅡ test can work efficiently as a triage of patients with ASCUS, LSIL and HSIL before colposcopically directed biopsies.
出处
《中国基层医药》
CAS
2007年第8期1270-1271,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
宫颈上皮内瘤样病变
乳头状瘤病毒
人
宫颈肿瘤
寡核苷酸序列分析
Cervical intraepithelial neoplasia
Papillomavirus, human
Cervix neoplasms
Oligonucleotide array sequence analysis
