摘要
目的探讨宫颈疾病的发病情况及特点，为宫颈癌的早期预防工作提供依据。方法2004年4月至2006年3月在计生站行宫颈细胞学检查、HPVDNA检测配合阴道镜检查对子宫颈病变进行筛查，以组织学为金标准，对结果进行分析。结果宫颈涂片11179例，异常涂片351例（3．41％）；宫颈HPV DNA检测11179例，阳性156例（1．395％）；阴道镜检查1140例，104例在阴道镜指引下宫颈活体组织检查。病理结果显示：宫颈上皮内瘤样变（CIN）83例（检出率7．9．81％），其中CINⅠ33例，CINⅡ10例，CINⅢ40例，HPV感染8例。HPV DNA检测阳性高峰年龄为30～34岁（31．41％），CIN发病年龄在30～44岁之间的病例占86．75％。宫颈轻度糜烂占发生CIN总数的33．73％，其中CINⅡ、CINⅢ分别占40％和30％，宫颈光滑者占CIN总数的28．92％。宫颈细胞学检查异常、HPV DNA检测阳性，活检确诊为CIN与宫颈细胞学检查异常而HPV DNA检测阴性活检确诊为CIN，经’0检验差异有统计学意义（P〈0．05）。宫颈涂片细胞学检查诊断CAN符合率86．30％；阴道镜检查对CIN的诊断符合率96．39％（80／83），两者比较差异有统计学意义（P〈0．05）。结论采用宫颈细胞学检查、HPVONA检测配合阴道镜下病理检查能及早发现宫颈癌的瘤前病变，30～44岁年龄妇女是宫颈癌防治的重点人群。对HPV阳性者要进行严格的宫颈癌追踪检查。
Objective To discuss the inddenee and characteristics of cervical disease and to offer the evidence for the early prophylaxis of cervical cancer. Methods From April in 2004 to March in 2006 , in service station for family planning,the cervical cytological test, HPV DNA test combinedwith colposcopy were used to diagnose the cervical diseases. The histology was used as gold standard, and the result was analyzed. Results 11179 cases of cervical smears,351 cases of abnormal smears（3.41%） .cervical HPV DNA test the 11179 cases, 156 cases of positive（1.395 % ）. use colposeopy test 1140 cases, 104 cases ware tested by used the cervical biopsy taken under the guidance of colposcopy for pathological examination. Pathological result showed 83 cases of CIN, among these cases： 33 cases of CIN Ⅰ ; 10 cases of CIN Ⅱ, 40 cases of CIN Ⅲ , 8 cases of HPV infections. HPV DNA was positive detected in the peak age of 30 to 34 years old（31 ： 41% ）. CIN incidence in the age between 30 to 44 years of age accounted for 86.75 % of the cases. CIN occurred mild cervical erosion accounted for 33.73 % of the total, were observed. CIN Ⅲ were 40 % and 30 % of the total number of cervical Smooth who accounted for 28.92 % of CIN. Abnormal cervical cytology and HPV DNA testing positive. CAN biopsy for abnormal cervical cytology and HPV DNA testing negative biopsy eonfirmed CAN, X2 test on the difference was significant（ P〈 0.05 ）. Palace CIN cervical cytological diagnosis rate 86. 3096 ;CIN eolposcopy in the diagnosis rate of 96.39 % （80/83）. Taken significant difference（ P 〈 0.05 ）. Conclusion Cervical cytology, HPV DNA testing with eolposcopy under pathological examination can earlier detect cervical precancerous lesions. Women aged 30 to 44 and the focus is on prevention Of cervical cancer. The HPV-positire cervical cancer should be strictly followed.
出处
《中国基层医药》
CAS
2007年第2期214-217,共4页
Chinese Journal of Primary Medicine and Pharmacy
