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Pokemon蛋白与肿瘤 被引量：1

Pokemon Protein and Tumors
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摘要 Pokemon(POK erythroid ontogenic factor)蛋白,即POK红系髓性致癌因子,是POK转录抑制物家簇的一个成员,为ZBTB7基因所编码的产物。Pokemon蛋白作为转录因子参与一些细胞基因转录的调节,并在细胞分化过程中发挥着关键、多效性的功能。近来发现,Poke-mon在致癌转化过程中发挥着至关重要的功能,并与肿瘤的发生密切相关。 Pokemon is also called POK erythroid ontogenic factor, which is a member of transcriptional repressor family of POK （POZ and Kruppel） and is the codogenic product of ZBTB7 gene, As transcription factor, Pokemon protein takes part in the regulations of some genes transcription and plays key and polyphonic function in cellular differentiation. Recent studies showed that Pokemon played a critical role in the transformation of carcinogenesis and has close relationship with tumorigenesis.
作者 徐海 崔明
机构地区 成都军区昆明总医院普通外科
出处 《医学综述》 2007年第20期1551-1553,共3页 Medical Recapitulate
关键词 POKEMON 癌基因 转录因子 细胞分化 肿瘤 Pokemon Oncogene Transcription factor Cellular differentiation Neoplasm
分类号 R730.2 [医药卫生—肿瘤]
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参考文献15

  • 1Pessler F, Pendergrast PS, Hemandez N. Purification and characteriza- tion of FBI-1, a cellular factor that binds to the human immunodeficiency vires type 1 inducer of short transcripts[J]. Mol Cell Biol, 1997,17 (7) : 3786-3798. 被引量：1
  • 2Morrison DJ, Pendergrast PS, Stavropoulos P, et al. FBI, a factor that binds to the HIV-1 inducer of short transcripts(IST), is a poz domain protein[J]. Nucleic Acid Res, 1999,5(27) : 1251-1262. 被引量：1
  • 3Davies JM, Hawe N, Kabarowski J, et al. Novel BTB/POZ domain zincfinger protein, LRF,is a potential target of the LAZ-3/BCL-6 oncogene[J]. Oncogene, 1999,18(2) :365-375. 被引量：1
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  • 5Dhordain P,Albagli O,Ansieau S, a al .The BTB/POZ domain targets the LAZ3/BCL6 oncoprotein to nuclear dots and mediates homomefisation in vivo [ J ]. Oncogene, 1995,11 ( 12 ) : 2689-2697. 被引量：1
  • 6Pendergrast PS, Wang C, Hernandez N, et al. FBI- 1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb--containing nuclear speckles[J]. Mol Biol Cell, 2002, 13(3) :915-929. 被引量：1
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  • 8Lee DK, Suh D, Edenberg HJ, et al. POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Spl[J] .J Biol Chem, 2002,277 ( 30 ) : 26761-26768. 被引量：1
  • 9Liu C J, Prazak L, Fajardo M, Yn S, et al. Leukemia/lymphoma-related factor, a POZ domain-containlng transcriptional repressor, interacts with bistone deacetylase-1 and inhibits cartilage oligomefic matrix protein gene expression and chondrogenesis [J]. J Biol Chem, 2004,279 ( 45 ) : 47081-47091. 被引量：1
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同被引文献7

  • 1Pessler F, Pendergrast PS, Hernandez N. Purification and characterization of FBI -1, a cellular factor that binds to the human immunodeficiency virus type 1 inducer of short transcripts[J]. Mol Cell BioI, 1997,17 (7): 3786-3798. 被引量：1
  • 2Stogios PJ, Chen L, Prive ee. Crystal structure of the BTB domain from the LRF /ZBTB7 transcriptional regulator [ JJ . Protein Sci, 2007, 16 (2): 336-342. 被引量：1
  • 3Schubot FD, Tropea JE, Waugh DS. Structure of the POZ domain of human LRF, a master regulator of oncogenesis [ J]. Biochem Biophys Res Commun, 2006, 351 (1): 1-6. 被引量：1
  • 4Kelly KF, Daniel JM. POZ for effect -- POZ-ZF transcription factors in cancer and development [ J J. Trends Cell BioI, 2006, 16 (11) : 578-587. 被引量：1
  • 5Maeda T, Hobbs RM, Merghoub T, et al. Role of the proto-oncogene Pokemon in cellular transformation and ARF repression[J]. Nature, 2005,433 (7023): 278-285. 被引量：1
  • 6Maeda T, Hobbs RM, Pandolfi PP. The transcription factor Pokemon , a new key player in cancer pathogenesis [ J ] . Cancer Res, 2005, 65 (19) : 8575 -8578. 被引量：1
  • 7赵心恺,宁巧明,孙晓宁,田德安.POKemon和NF-κB p65在肝癌细胞中的信号调控[J].肿瘤,2012,32(1):32-37. 被引量：4

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医学综述
2007年 第20期

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