摘要
目的:探讨利培酮与氯氮平对儿童心电图的影响。方法:采用随机分组方法,将98例儿童精神分裂症患者随机分为利培酮组50例和氯氮平组48例,治疗8周,分别定期检查心电图,时间分别为治疗前和治疗后第1、2、4、6、8周末,并进行比较分析。结果:治疗前两组心电图均正常。治疗后利培酮与氯氮平对心电图改变的发生率分别为23.6%、42.5%,差异极显著(χ2=19.83,P<0.01)。显著异常时段为第4周末。两组均以窦性心动过速、窦性心律不齐和ST-T改变多见,但利培酮组窦性心动过速和ST-T改变发生率明显低于氯氮平组,而窦性心动过缓和窦性心律不齐明显高于氯氮平组。结论:利培酮对儿童心电图的影响显著低于氯氮平。
Objectives: Take a look at the effects of risperidone and clozapine on Electrocardiogram (ECG) of child. Methods: To adopt the random method of dividing into groups ,will 98 regular children Schizophrenic random divide into rispefidone group (50 example) with clrozapine group (48 examples)treatment 8 weeks, inspect electrocardiogram respectively and regularly, before treatment and 1.2.4.6.8 weeks after treatment,ECG were conducted and compared for the 2 groups. Results: Before treatment, ECG of both 2 groups were normal. After treatment, the percentage effect on ECG caused by fispefidone and clozapine were 23.6% .42.5% respectively. The most significant differences existed between fispefidone and clozapine ( X^2 = 19.83, P 〈 0.01 ). Obvious abnormality occurred at the end of the 4th week. Sinus tachycardia, sinus arrhythmia and ST - T change were common in both the 2 groups, but incidence rate of sinus tachycardia or ST-T change were lower and that of sinus arrhythmia or sinus bradycardia higher in the risperidone than in the clozapine group. Conclusion: The study suggests that the effects of fispefidone on child electrocardiogram (ECG) are less than clozapine.
出处
《赣南医学院学报》
2007年第4期534-535,547,共3页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
利培酮
氯氮平
儿童
心电图
Risperidone
Clozapine
Child
Electrocardiogram (ECG)