摘要
在过去的40年里,治疗严重慢性疼痛一直没有理想的药物。随着对离子通道与疼痛的深入研究,现已研发出一个具有全新作用机制的肽类药物齐考诺肽(ziconotide),它通过阻断N型钙离子通道而达到镇痛的目的。目前,齐考诺肽在欧美国家已上市,其对慢性疼痛镇痛的疗效和安全性得到确证。以N型钙离子通道为靶标研发新型慢性疼痛镇痛药受到药理研究者和临床工作者的广泛重视,这为无成瘾性镇痛药的研究指出了新的发展方向。简要阐述了齐考诺肽的结构、主要药理作用机制、应用现状及前景等。
For the past 40 years, there has been no major addition to the repertoire of drugs for treating severe, chronic pain. Now, ziconotide, with a completely different mechanism of action, targeting N-type calcium channels, is making its market debuts in the US and Europe-milestones that have received remarkably attention. This article briefly reviews their structure, pharmacological activities, as well as their potential applications.
出处
《生物技术通讯》
CAS
2007年第5期885-887,共3页
Letters in Biotechnology
基金
国家重点基础研究发展规划项目(2003CB515406)
国家自然科学资金项目(30371677)
关键词
N型钙通道
齐考诺肽
疼痛
N-type calcium channel
ziconotide
pain
