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甲地孕酮对低体重慢性阻塞性肺疾病患者生活质量影响

Effect of megestrol acetate on quality of life in underweight chronic obstructive pulmonary disease patients
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摘要 目的探讨甲地孕酮(MA)对慢性阻塞性肺疾病(COPD)患者体重、肺功能和运动耐量的影响。方法将42例低体重COPD患者随机分为MA组(口服MA 160 mg/d)和对照组(单纯支持治疗),观察8周,比较两组体重、肺功能、动脉血气分析及6 min步行距离(6MWD)的变化。结果MA组体重和前白蛋白增加(P〈0.05);MA组动脉血二氧化碳分压(PaCO2)下降,动脉血氧分压(PaO2)升高(P〈0.05),FEV1和FVC差异无统计学意义(P〉0.05);两组6MWD差异无统计学意义(P〉0.05)。结论MA能改善低体重慢性阻塞性肺疾病患者体重和肺通气功能,但不能增加运动耐量。 Objective To assess the effect of MA on body weight,and exercise endurance in COPD patients. Methods Forty- two underweight COPD patients were divided into two groups randomly, Either MA, 160 mg/d oral or placebo for 8 weeks. Results Body weight were significantly increased in patients with MA group than that in the controls ( P 〈 0.05 ), PaCO2 decreased and PaO2 increased ( P 〈 0.05 ) in the MA group. FEV1 and FVC showed no significant changes from baseline in either group. The 6 - min walk distances did not differ statistically between groups. Conclusion MA increased body weight, stimulated ventilation in underweight COPD patients, but did not improve exercise tolerance.
出处 《中原医刊》 2007年第16期10-11,共2页 Central Plains Medical Journal
关键词 甲地孕酮 慢性阻塞性肺疾病 低体重 Megestrol acetate :COPD. Underweight
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