摘要
我们通过免疫组织化学方法对5例正常肾组织和45例肾癌组织中P53和c－myc蛋白的表达水平进行检测。结果发现：5例正常肾组织中未见这两种蛋白表达。45例肾癌中P53和C－myc阳性表达率分别为（40％）18／45和（26．7％）12／45，阳性表达的C－myc和P53蛋白均定位于肾癌细胞核内，并且C－myc和P53蛋白阳性表达率与肾癌的病理分级，临床分期及患者术后生存期有关。提示P53和C－myc蛋白阳性表达与肾癌发生和发展有关，并且有可能成为评价肾癌预后的新指标。
Using immunohistochemical method, we performed the expression of P53 and C-myc in the normal renal tissues and renal cancer tissues. none of the proteins were expressed in o normal renal tissues. The positive rates of P53 and C-myc in renal cancer were 18/45 and 12/45 respectively, and C-myc and P53 proteins were located in nuclei in renal cancer. The expression of C-myc and P53 were associated with the stage, grade and survival rates of renal cancer. These results suggest that C-myc and P53 play a role in the development of renal cancer, and become a new marker of progonsis of renal cancer.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1997年第2期67-68,71,共3页
Cancer Research on Prevention and Treatment
